SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2012
Advanced age is a risk factor for post-operative complications and mortality after a pancreaticoduodenectomy: a meta-analysis and systematic review.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 75 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis.Age and ageing · 2024Pooled it
- Laparoscopic Pancreaticoduodenectomy in Elderly Patients: Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- The impact of venous resection in pancreatoduodectomy: A systematic review and meta-analysis.Medicine · 2021Pooled it
- Risk factors and preventive strategies for post-operative pancreatic fistula after pancreatic surgery: a comprehensive review.Scandinavian journal of gastroenterology · 2016Pooled it
- Impact of age on safety of pancreaticoduodenectomy: a nationwide cohort study stratified by surgical approach and anastomotic technique with optimal age cut-off analysis.Science China. Life sciences · 2026Article
- Understanding pancreatic reconstruction after pancreatoduodenectomy: lessons in technique and biology.Gland surgery · 2026Article
- Short-term surgical outcomes for patients with non-functional pancreatic neuroendocrine tumors are unaffected by chronological age.Surgery open science · 2026Article
- The Price of a Whipple: Predicting Hospital Charges Using Preoperative Patient Characteristics.World journal of surgery · 2026Article
- Textbook outcome following pancreaticoduodenectomy in elderly patients: age-stratified analysis and predictive factors.Updates in surgery · 2025Article
- Ligation of the Pancreatic Stump With Quantified Force During Distal Pancreatectomy for Postoperative Pancreatic Fistula: Protocol for a Single-Center Nonrandomized Controlled Clinical Study.JMIR research protocols · 2025Article
- Enhancing meat-type chicken performance throughArchives animal breeding · 2025Article
- A new perspective on post-operative pancreatic fistulas: the impact of post-pancreatectomy acute pancreatitis.Gland surgery · 2024Article
- Pancreaticoduodenectomy for octogenarians under postoperative rehabilitation enhanced ERAS protocol.BMC surgery · 2024Article
- Colombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery - a prospective cohort study.Lancet regional health. Americas · 2024Article
- Impact ofVeterinary sciences · 2024Article
- The impact of geriatric-specific variables on long-term outcomes in patients with hepatopancreatobiliary and colorectal cancer selected for resection.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2024Observational
- Safety and Feasibility of Neoadjuvant-Modified FOLFIRINOX in Elderly Patients with Pancreatic Cancer.Cancers · 2024Article
- Update on the management of older patients with pancreatic adenocarcinoma: a perspective from medical oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Review
- Magnitude and associated factors of postoperative mortality among patients who underwent surgery in Ethiopia: systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
- Prevalence of and risk factors for surgical site infections after pancreaticoduodenectomy: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issuedPrashant, Sukharamwala [corrected to Sukharamwala, Prashant]; Jonathan, Thoens [corrected to Thoens, Jonathan]; Mauricio, Szuchmacher [corrected to Szuchmacher, Mauricio]; James, Smith [corrected to Smith, James]; Peter, DeVito [corrected to DeVito, Peter]
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this meta-analysis was to analyse the outcomes of major pancreatic surgery among the elderly (≥75 and ≥80 years of age).
methodsA systematic literature search was conducted using Embase, MEDLINE, Cochrane and PubMed databases on all studies published between January 1990 and April 2012 reporting peri-operative outcomes after a pancreaticoduodenectomy (PD) among the elderly. Primary end-points measured were peri-operative mortality and the incidence of post-operative complications. Secondary outcomes considered included the incidence of post-operative pancreatic fistula formation (POPF), delayed gastric emptying (DGE), wound infection, pneumonia, post-operative bleeding and length of hospital stay.
resultsEleven trials were included comprising 5186 patients; 7 studies comparing endpoints in patients aged ≥75 years vs. younger populations and 4 studies comparing endpoints in patients aged ≥80 years vs. younger populations. In both groups, there was a statistically significant increase in the incidence of mortality and post-operative pneumonia in the elderly population. The incidence of post-operative complications was also found to be statistically significant among patients ≥80 years of age vs. their younger cohorts.
conclusionsThere is an increased incidence of post-operative mortality and pneumonia after a PD among all elderly patients ≥75 years of age, as well as an increased incidence of post-operative complications among patients ≥80 years of age. Additional randomized control trials studying post-PD operative outcomes in elderly vs. younger patients with standardization of comorbidities is therefore necessary to confirm the conclusions presented here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.