ArticleBMC genomics2012
Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Clinical Diagnostic Implications of Body Fluid MiRNA in Oral Squamous Cell Carcinoma: A Meta-Analysis.Medicine · 2015Pooled it
- MicroRNAs: exploring their role in farm animal disease and mycotoxin challenges.Frontiers in veterinary science · 2024Review
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- Comparative Mucous miRomics in Cynoglossus semilaevis Related to Vibrio harveyi Caused Infection.Marine biotechnology (New York, N.Y.) · 2021Article
- Integrative Analysis of miRNA and mRNA Expression Profiles in Mammary Glands of Holstein Cows Artificially Infected withPathogens (Basel, Switzerland) · 2021Article
- miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies.International journal of molecular sciences · 2021Review
- Expressions of miR-155 and miR-181 and predictions of their structures and targets in pigs (Veterinary world · 2020Article
- Global Gene Networks in 3D4/31 Porcine Alveolar Macrophages Treated with Antigenic Epitopes of Actinobacillus pleuropneumoniae ApxIA, IIA, and IVA.Scientific reports · 2019Article
- Differentially Expressed MiRNAs and tRNA Genes Affect Host Homeostasis During Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infections in Young Pigs.Frontiers in genetics · 2019Article
- Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection.Veterinary research · 2018Article
- IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs.PloS one · 2018Article
- Molecular approaches to the diagnosis and monitoring of production diseases in pigs.Research in veterinary science · 2017Review
- ssc-miR-7134-3p regulates fat accumulation in castrated male pigs by targetingInternational journal of biological sciences · 2017Article
- Differential MicroRNA Analyses ofInternational journal of genomics · 2017Article
- Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum.Veterinary research · 2016Article
- miR-628, a microRNA that is induced by Toll-like receptor stimulation, regulates porcine innate immune responses.Scientific reports · 2015Article
- Difference in microRNA expression and editing profile of lung tissues from different pig breeds related to immune responses to HP-PRRSV.Scientific reports · 2015Article
- Current transcriptomics in pig immunity research.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Review
- A MicroRNA-Transcription Factor Blueprint for Early Atrial Arrhythmogenic Remodeling.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) are a class of non-protein-coding genes that play a crucial regulatory role in mammalian development and disease. Whereas a large number of miRNAs have been annotated at the structural level during the latest years, functional annotation is sparse. Actinobacillus pleuropneumoniae (APP) causes serious lung infections in pigs. Severe damage to the lungs, in many cases deadly, is caused by toxins released by the bacterium and to some degree by host mediated tissue damage. However, understanding of the role of microRNAs in the course of this infectious disease in porcine is still very limited.
resultsIn this study, the RNA extracted from visually unaffected and necrotic tissue from pigs infected with Actinobacillus pleuropneumoniae was subjected to small RNA deep sequencing. We identified 169 conserved and 11 candidate novel microRNAs in the pig. Of these, 17 were significantly up-regulated in the necrotic sample and 12 were down-regulated. The expression analysis of a number of candidates revealed microRNAs of potential importance in the innate immune response. MiR-155, a known key player in inflammation, was found expressed in both samples. Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection.
conclusionsThis is the first study revealing significant differences in composition and expression profiles of miRNAs in lungs infected with a bacterial pathogen. Our results extend annotation of microRNA in pig and provide insight into the role of a number of microRNAs in regulation of bacteria induced immune and inflammatory response in porcine lung.
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