ArticlePloS one2012
Phylogenetic evidence that two distinct Trichuris genotypes infect both humans and non-human primates.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections.Nature communications · 2025Article
- Using Biocontrol Fungi to Control Helminthosis in Wild Animals: An Innovative Proposal for the Health and Conservation of Species.Pathogens (Basel, Switzerland) · 2025Review
- Nematode diversity in Mastomys rodents (Rodentia: Muridae) across a wildlife-human/domestic animal interface and molecular characterization of Trichuris species from M. natalensis.Parasitology research · 2025Article
- Trichuriasis in Human Patients from Côte d'Ivoire Caused by Novel Trichuris incognita Species with Low Sensitivity to Albendazole/Ivermectin Combination Treatment.Emerging infectious diseases · 2025Article
- Phylogenetic evidence of a possibleParasitology · 2024Article
- De novo assembled mitogenome analysis of Trichuris trichiura from Korean individuals using nanopore-based long-read sequencing technology.PLoS neglected tropical diseases · 2023Article
- A new record of the occurrence of Trichuris skrjabini Baskakov, 1924 in goats of Pakistan.PloS one · 2023Article
- Population genomics of ancient and modern Trichuris trichiura.Nature communications · 2022Article
- The Use of MALDI-TOF MS as a Diagnostic Tool for AdultFrontiers in veterinary science · 2022Article
- Soil-transmitted helminth infections in free-ranging non-human primates from Cameroon and Gabon.Parasites & vectors · 2021Article
- Efficacy of Fenbendazole and Ivermectin againstJournal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Genetic characterization of nodular worm infections in Asian Apes.Scientific reports · 2021Article
- Complete Mitochondrial Genome ofLife (Basel, Switzerland) · 2021Article
- Review
- Nuclear and Mitochondrial Data onLife (Basel, Switzerland) · 2020Article
- Trichuris trichiura isolated from Macaca sylvanus: morphological, biometrical, and molecular study.BMC veterinary research · 2020Article
- Differentiation ofInternational journal for parasitology. Parasites and wildlife · 2020Article
- Article
- Differentiation ofInternational journal for parasitology. Parasites and wildlife · 2019Article
- Infection dynamics of gastrointestinal helminths in sympatric non-human primates, livestock and wild ruminants in Kenya.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there has been extensive debate about whether Trichuris suis and Trichuris trichiura are separate species, only one species of the whipworm T. trichiura has been considered to infect humans and non-human primates. In order to investigate potential cross infection of Trichuris sp. between baboons and humans in the Cape Peninsula, South Africa, we sequenced the ITS1-5.8S-ITS2 region of adult Trichuris sp. worms isolated from five baboons from three different troops, namely the Cape Peninsula troop, Groot Olifantsbos troop and Da Gama Park troop. This region was also sequenced from T. trichiura isolated from a human patient from central Africa (Cameroon) for comparison. By combining this dataset with Genbank records for Trichuris isolated from other humans, non-human primates and pigs from several different countries in Europe, Asia, and Africa, we confirmed the identification of two distinct Trichuris genotypes that infect primates. Trichuris sp. isolated from the Peninsula baboons fell into two distinct clades that were found to also infect human patients from Cameroon, Uganda and Jamaica (named the CP-GOB clade) and China, Thailand, the Czech Republic, and Uganda (named the DG clade), respectively. The divergence of these Trichuris clades is ancient and precedes the diversification of T. suis which clustered closely to the CP-GOB clade. The identification of two distinct Trichuris genotypes infecting both humans and non-human primates is important for the ongoing treatment of Trichuris which is estimated to infect 600 million people worldwide. Currently baboons in the Cape Peninsula, which visit urban areas, provide a constant risk of infection to local communities. A reduction in spatial overlap between humans and baboons is thus an important measure to reduce both cross-transmission and zoonoses of helminthes in Southern Africa.
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