ArticlePloS one2012
Adenosine deaminase polymorphism affects sleep EEG spectral power in a large epidemiological sample.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- A Lightweight Temporal-Spatial Fusion Network for Neonatal Sleep Staging.Bioengineering (Basel, Switzerland) · 2026Article
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- Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives.Journal of sleep research · 2022Review
- Interaction between cocaine use and sleep behavior: A comprehensive review of cocaine's disrupting influence on sleep behavior and sleep disruptions influence on reward seeking.Pharmacology, biochemistry, and behavior · 2021Review
- A Functional Adenosine Deaminase Polymorphism Associates with Evening Melatonin Levels and Sleep Quality.Journal of circadian rhythms · 2021Article
- Sleep- and time of day-linked RNA transcript expression in wild-type and IL1 receptor accessory protein-null mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- A single nucleotide polymorphism in the HOMER1 gene is associated with sleep latency and theta power in sleep electroencephalogram.PloS one · 2020Article
- Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults.Current neurology and neuroscience reports · 2017Review
- TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations.Scientific reports · 2017Article
- Human genetics and sleep behavior.Current opinion in neurobiology · 2017Review
- Pleiotropic genetic effects influencing sleep and neurological disorders.The Lancet. Neurology · 2017Review
- Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine.Biology · 2016Review
- Article
- The adenosine deaminase gene polymorphism is associated with chronic heart failure risk in Chinese.International journal of molecular sciences · 2014Article
- Genetic psychophysiology: advances, problems, and future directions.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2014Review
- The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements.PloS one · 2014Article
- Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile.Frontiers in aging neuroscience · 2014Article
- About sleep's role in memory.Physiological reviews · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slow wave oscillations in the electroencephalogram (EEG) during sleep may reflect both sleep need and intensity, which are implied in homeostatic regulation. Adenosine is strongly implicated in sleep homeostasis, and a single nucleotide polymorphism in the adenosine deaminase gene (ADA G22A) has been associated with deeper and more efficient sleep. The present study verified the association between the ADA G22A polymorphism and changes in sleep EEG spectral power (from C3-A2, C4-A1, O1-A2, and O2-A1 derivations) in the Epidemiologic Sleep Study (EPISONO) sample from São Paulo, Brazil. Eight-hundred individuals were subjected to full-night polysomnography and ADA G22A genotyping. Spectral analysis of the EEG was carried out in all individuals using fast Fourier transformation of the signals from each EEG electrode. The genotype groups were compared in the whole sample and in a subsample of 120 individuals matched according to ADA genotype for age, gender, body mass index, caffeine intake status, presence of sleep disturbance, and sleep-disturbing medication. When compared with homozygous GG genotype carriers, A allele carriers showed higher delta spectral power in Stage 1 and Stages 3+4 of sleep, and increased theta spectral power in Stages 1, 2 and REM sleep. These changes were seen both in the whole sample and in the matched subset. The higher EEG spectral power indicates that the sleep of individuals carrying the A allele may be more intense. Therefore, this polymorphism may be an important source of variation in sleep homeostasis in humans, through modulation of specific components of the sleep EEG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.