ArticlePloS one2012
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Animal Models of Malaria-Associated Acute Kidney Injury.Seminars in nephrology · 2025Review
- Hypoxia and collagen deposition in the kidneys infected with Acanthamoeba sp.Scientific reports · 2024Article
- Involvement of Inflammatory Cytokines, Renal NaPi-IIa Cotransporter, and TRAIL Induced-Apoptosis in Experimental Malaria-Associated Acute Kidney Injury.Pathogens (Basel, Switzerland) · 2024Article
- The role of apoptosis and oxidative stress in the pathophysiology of Acanthamoeba spp. infection in the kidneys of hosts with different immunological status.Parasites & vectors · 2023Article
- Novel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury.Pathogens (Basel, Switzerland) · 2023Article
- In vitro and in vivo antiplasmodial activities of leaf extracts from Sonchus arvensis L.BMC complementary medicine and therapies · 2023Article
- Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment.Frontiers in cellular and infection microbiology · 2022Article
- Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis.International journal of molecular sciences · 2021Article
- Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections.International journal of molecular sciences · 2021Review
- Protective Effects ofJournal of parasitology research · 2021Article
- Expression of 4-Hydroxynonenal (4-HNE) and Heme Oxygenase-1 (HO-1) in the Kidneys ofJournal of tropical medicine · 2020Article
- Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research.Experimental animals · 2019Review
- Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner.The Korean journal of parasitology · 2019Article
- TREM-1 modulation produces positive outcome on the histopathology and cytokines release profile ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- Article
- TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation.Oxidative medicine and cellular longevity · 2019Article
- The angiotensin II/AT1 receptor pathway mediates malaria-induced acute kidney injury.PloS one · 2018Article
- Ambivalent Outcomes of Cell Apoptosis: A Barrier or Blessing in Malaria Progression.Frontiers in microbiology · 2016Review
- Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice.Journal of tropical medicine · 2015Article
- Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice.Journal of pathogens · 2015Article
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the causes that lead to a framework of malaria-associated AKI are still poorly characterized. Some clinical studies speculate that oxidative stress products, a characteristic of Plasmodium infection, as well as proinflammatory response induced by the parasite are involved in its pathophysiology. Therefore, we aimed to investigate the development of malaria-associated AKI during infection by P. berghei ANKA, with special attention to the role played by the inflammatory response and the involvement of oxidative stress. For that, we took advantage of an experimental model of severe malaria that showed significant changes in the renal pathophysiology to investigate the role of malaria infection in the renal microvascular permeability and tissue injury. Therefore, BALB/c mice were infected with P. berghei ANKA. To assess renal function, creatinine, blood urea nitrogen, and ratio of proteinuria and creatininuria were evaluated. The products of oxidative stress, as well as cytokine profile were quantified in plasma and renal tissue. The change of renal microvascular permeability, tissue hypoxia and cellular apoptosis were also evaluated. Parasite infection resulted in renal dysfunction. Furthermore, we observed increased expression of adhesion molecule, proinflammatory cytokines and products of oxidative stress, associated with a decrease mRNA expression of HO-1 in kidney tissue of infected mice. The measurement of lipoprotein oxidizability also showed a significant increase in plasma of infected animals. Together, our findings support the idea that products of oxidative stress, as well as the immune response against the parasite are crucial to changes in kidney architecture and microvascular endothelial permeability of BALB/c mice infected with P. berghei ANKA.
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