ArticlePloS one2012
Staphylococcus aureus methicillin-resistance factor fmtA is regulated by the global regulator SarA.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
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- An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus.Microbiology and molecular biology reviews : MMBR · 2022Review
- Phenotypic and genotypic changes of Staphylococcus aureus in the presence of the inappropriate concentration of chlorhexidine gluconate.BMC microbiology · 2022Article
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- Staphylococcus aureus biofilm organization modulated by YycFG two-component regulatory pathway.Journal of orthopaedic surgery and research · 2019Article
- Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediateInfection and drug resistance · 2018Article
- Insights into the regulation of small RNA expression: SarA represses the expression of two sRNAs in Staphylococcus aureus.Nucleic acids research · 2016Article
- Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms.Antimicrobial agents and chemotherapy · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
fmtA encodes a low-affinity penicillin binding protein in Staphylococcus aureus. It is part of the core cell wall stimulon and is involved in methicillin resistance in S. aureus. Here, we report that the transcription factor, SarA, a pleiotropic regulator of virulence genes in S. aureus, regulates the expression of fmtA. In vitro binding studies with purified SarA revealed that it binds to specific sites within the 541-bp promoter region of fmtA. Mutation of a key residue of the regulatory activity of SarA (Arg90) abolished binding of SarA to the fmtA promoter, suggesting that SarA binds specifically to the fmtA promoter region. In vivo analysis of the fmtA promoter using a lux operon reporter fusion show high level expression following oxacillin induction, which was abrogated in a sarA mutant strain. These data suggest that SarA is essential for the induction of fmtA expression by cell wall-specific antibiotics. Further, in vitro transcription studies show that SarA enhances fmtA transcription and suggest that regulation of fmtA could be via a SigA-dependent mechanism. Overall, our results show that SarA plays a direct role in the regulation of fmtA expression via binding to the fmtA promoter.
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