ArticlePloS one2012
Guillain-Barré syndrome-related Campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Genomic variability of lipooligosaccharide biosynthesis locus and sequence type amongMicrobiology spectrum · 2025Article
- Detection ofVeterinary world · 2024Article
- Interleukin-10 promoter polymorphisms and haplotypes in patients with Guillain-Barré syndrome.Annals of clinical and translational neurology · 2024Article
- Campylobacter jejuni: targeting host cells, adhesion, invasion, and survival.Applied microbiology and biotechnology · 2023Review
- Immune-Mediated Neuropathies: Pathophysiology and Management.International journal of molecular sciences · 2023Review
- Draft Genome Sequences of Four Strains of Campylobacter jejuni Isolated from Patients with Axonal Variant of Guillain-Barré Syndrome in Bangladesh.Microbiology resource announcements · 2022Article
- An Automated Approach to Assess Relative Galectin-Glycan Affinity Following Glycan Microarray Analysis.Frontiers in molecular biosciences · 2022Article
- Draft Genome Sequences of Three Strains of Campylobacter jejuni Isolated from Patients with Guillain-Barré Syndrome in Bangladesh.Microbiology resource announcements · 2021Article
- Electrophysiology of Guillain-Barré syndrome in Bangladesh: A prospective study of 312 patients.Clinical neurophysiology practice · 2021Article
- Prevalence and Antimicrobial Resistance ofBioMed research international · 2021Article
- Cytokines and Soluble HLA-G Levels in the Acute and Recovery Phases of Arbovirus-Infected Brazilian Patients Exhibiting Neurological Complications.Frontiers in immunology · 2021Article
- Fc-gamma IIIa-V158F receptor polymorphism contributes to the severity of Guillain-Barré syndrome.Annals of clinical and translational neurology · 2020Article
- Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA AgainstFrontiers in immunology · 2020Article
- A high-resolution genomic composition-based method with the ability to distinguish similar bacterial organisms.BMC genomics · 2019Article
- Human leukocyte antigen-DQB1 polymorphisms and haplotype patterns in Guillain-Barré syndrome.Annals of clinical and translational neurology · 2019Article
- Toll-like receptor-4 299Gly allele is associated with Guillain-Barré syndrome in Bangladesh.Annals of clinical and translational neurology · 2019Article
- Reaction of antibodies toWorld journal of gastroenterology · 2019Article
- Zika Virus as an Emerging Neuropathogen: Mechanisms of Neurovirulence and Neuro-Immune Interactions.Molecular neurobiology · 2018Review
- Guillain-Barré syndrome following varicella-zoster virus infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Whole Genome Sequencing and Multiplex qPCR Methods to IdentifyFrontiers in microbiology · 2018Article
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCampylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C. jejuni lipo-oligosaccharides (LOS) precipitate the development of GBS, although this mechanism has not been established in patients from developing countries. We determined the carbohydrate mimicry between C. jejuni LOS and gangliosides, and the cross-reactive antibody response in patients with GBS in Bangladesh. METHODOLOGY: Sera from 97 GBS patients, and 120 neurological and family controls were tested for antibody reactivity against LOS from C. jejuni isolates from GBS patients in Bangladesh (BD-07, BD-39, BD-10, BD-67 and BD-94) by enzyme-linked immunosorbent assay (ELISA). Cross-reactivity to LOS was determined by ELISA. The LOS outer core structures of C. jejuni strains associated with GBS/MFS were determined by mass spectrometry. PRINCIPLE
findingsIgG antibodies to LOS from C. jejuni BD-07, BD-39, BD-10, and BD-67 IgG antibodies were found in serum from 56%, 58%, 14% and 15% of GBS patients respectively, as compared to very low frequency (<3%) in controls (p<0.001). Monoclonal antibodies specific for GM1 and GD1a reacted strongly with LOS from the C. jejuni strains (BD-07 and BD-39). Mass spectrometry analysis confirmed the presence of GM1 and GD1a carbohydrate mimics in the LOS from C. jejuni BD-07 and BD-39. Both BD-10 and BD-67 express the same LOS outer core, which appears to be a novel structure displaying GA2 and GD3 mimicry. Up to 90-100% of serum reactivity to gangliosides in two patients (DK-07 and DK-39) was inhibited by 50 µg/ml of LOS from the autologous C. jejuni isolates. However, patient DK-07 developed an anti-GD1a immune response while patient DK-39 developed an anti-GM1 immune response.
conclusionCarbohydrate mimicry between C. jejuni LOS and gangliosides, and cross-reactive serum antibody precipitate the majority of GBS cases in Bangladesh.
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