Trial reportPloS one2012
Theta oscillations are sensitive to both early and late conflict processing stages: effects of alcohol intoxication.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Effects of Age and Acute Moderate Alcohol Administration on Neurophysiology During Simulated Driving.Alcoholism, clinical and experimental research · 2016Trial
- Effects of acute alcohol intoxication on saccadic conflict and error processing.Psychopharmacology · 2013Trial
- A History of Methamphetamine Use Disorder in People with HIV Is Associated with Altered Functional Response to Risky Choice.Viruses · 2026Article
- Oscillatory and behavioral indices of cognitive control dysregulation in young adult binge drinkers are influenced by sex differences.Alcohol, clinical & experimental research · 2026Article
- Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect.Addiction neuroscience · 2025Article
- Neural indices of heritable impulsivity: Impact of the COMT Val158Met polymorphism on frontal beta power during early motor preparation.Biological psychology · 2024Article
- fMRI BOLD and MEG theta power reflect complementary aspects of activity during lexicosemantic decision in adolescents with ASD.Neuroimage. Reports · 2022Article
- Theta oscillatory dynamics of inhibitory control, error processing, and post-error adjustments: Neural underpinnings and alcohol-induced dysregulation in social drinkers.Alcoholism, clinical and experimental research · 2022Article
- Resting-state theta activity is linked to information content-specific coding levels during response inhibition.Scientific reports · 2022Article
- Inhibitory Control of Emotional Interference in Deaf Children: Evidence From Event-Related Potentials and Event-Related Spectral Perturbation Analysis.Frontiers in psychiatry · 2022Article
- Cognitive Control Promotes Either Honesty or Dishonesty, Depending on One's Moral Default.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Understanding ethanol's acute effects on medial prefrontal cortex neural activity using state-space approaches.Neuropharmacology · 2021Review
- Compensatory neuroadaptation to binge drinking: Human evidence for allostasis.Addiction biology · 2021Article
- The "when" and "where" of the interplay between attentional capture and response inhibition during a Go/NoGo variant.NeuroImage · 2021Article
- MEG Theta during Lexico-Semantic and Executive Processing Is Altered in High-Functioning Adolescents with Autism.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Binge drinking is associated with altered resting state functional connectivity of reward-salience and top down control networks.Brain imaging and behavior · 2020Article
- Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment?Frontiers in psychiatry · 2020Review
- Neural oscillatory dynamics of inhibitory control in young adult binge drinkers.Biological psychology · 2019Article
- Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach.Journal of psychopharmacology (Oxford, England) · 2019Article
- Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication.Journal of visualized experiments : JoVE · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Prior neuroimaging evidence indicates that decision conflict activates medial and lateral prefrontal and parietal cortices. Theoretical accounts of cognitive control highlight anterior cingulate cortex (ACC) as a central node in this network. However, a better understanding of the relative primacy and functional contributions of these areas to decision conflict requires insight into the neural dynamics of successive processing stages including conflict detection, response selection and execution. Moderate alcohol intoxication impairs cognitive control as it interferes with the ability to inhibit dominant, prepotent responses when they are no longer correct. To examine the effects of moderate intoxication on successive processing stages during cognitive control, spatio-temporal changes in total event-related theta power were measured during Stroop-induced conflict. Healthy social drinkers served as their own controls by participating in both alcohol (0.6 g/kg ethanol for men, 0.55 g/kg women) and placebo conditions in a counterbalanced design. Anatomically-constrained magnetoencephalography (aMEG) approach was applied to complex power spectra for theta (4-7 Hz) frequencies. The principal generator of event-related theta power to conflict was estimated to ACC, with contributions from fronto-parietal areas. The ACC was uniquely sensitive to conflict during both early conflict detection, and later response selection and execution stages. Alcohol attenuated theta power to conflict across successive processing stages, suggesting that alcohol-induced deficits in cognitive control may result from theta suppression in the executive network. Slower RTs were associated with attenuated theta power estimated to ACC, indicating that alcohol impairs motor preparation and execution subserved by the ACC. In addition to their relevance for the currently prevailing accounts of cognitive control, our results suggest that alcohol-induced impairment of top-down strategic processing underlies poor self-control and inability to refrain from drinking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.