ArticlePloS one2012
In vivo quantification reveals extensive natural variation in mitochondrial form and function in Caenorhabditis briggsae.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Evidence of compensation for mitochondrial reactive oxygen species increase inmicroPublication biology · 2024Article
- Thermal Adaptations in Animals: Genes, Development, and Evolution.Advances in experimental medicine and biology · 2024Review
- Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes.Current opinion in genetics & development · 2023Review
- Article
- Complex Transmission Patterns and Age-Related Dynamics of a Selfish mtDNA Deletion.Integrative and comparative biology · 2019Article
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos.Human reproduction (Oxford, England) · 2019Article
- Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes.Fertility and sterility · 2018Article
- Mitochondrial Subtype Identification and Characterization.Current protocols in cytometry · 2018Article
- Adaptive Evolution under Extreme Genetic Drift in Oxidatively Stressed Caenorhabditis elegans.Genome biology and evolution · 2017Article
- "High-Throughput Characterization of Region-Specific Mitochondrial Function and Morphology".Scientific reports · 2017Article
- Cytoplasmic-Nuclear Incompatibility Between Wild Isolates ofG3 (Bethesda, Md.) · 2017Article
- Paternal Mitochondrial Transmission in Intra-Species Caenorhabditis briggsae Hybrids.Molecular biology and evolution · 2016Article
- Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.Cell metabolism · 2016Article
- Identification and Characterization of Mitochondrial Subtypes in Caenorhabditis elegans via Analysis of Individual Mitochondria by Flow Cytometry.Analytical chemistry · 2016Article
- Mitochondrial-Nuclear Epistasis Impacts Fitness and Mitochondrial Physiology of Interpopulation Caenorhabditis briggsae Hybrids.G3 (Bethesda, Md.) · 2015Article
- Selfish Mitochondrial DNA Proliferates and Diversifies in Small, but not Large, Experimental Populations of Caenorhabditis briggsae.Genome biology and evolution · 2015Article
- Endogenous ROS levels in C. elegans under exogenous stress support revision of oxidative stress theory of life-history tradeoffs.BMC evolutionary biology · 2014Article
- Evolution of a higher intracellular oxidizing environment in Caenorhabditis elegans under relaxed selection.PloS one · 2013Article
- Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway.International journal of nanomedicine · 2013Article
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5 authors.
Funding
Abstract
We have analyzed natural variation in mitochondrial form and function among a set of Caenorhabditis briggsae isolates known to harbor mitochondrial DNA structural variation in the form of a heteroplasmic nad5 gene deletion (nad5Δ) that correlates negatively with organismal fitness. We performed in vivo quantification of 24 mitochondrial phenotypes including reactive oxygen species level, membrane potential, and aspects of organelle morphology, and observed significant among-isolate variation in 18 traits. Although several mitochondrial phenotypes were non-linearly associated with nad5Δ levels, most of the among-isolate phenotypic variation could be accounted for by phylogeographic clade membership. In particular, isolate-specific mitochondrial membrane potential was an excellent predictor of clade membership. We interpret this result in light of recent evidence for local adaptation to temperature in C. briggsae. Analysis of mitochondrial-nuclear hybrid strains provided support for both mtDNA and nuclear genetic variation as drivers of natural mitochondrial phenotype variation. This study demonstrates that multicellular eukaryotic species are capable of extensive natural variation in organellar phenotypes and highlights the potential of integrating evolutionary and cell biology perspectives.
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