ArticlePloS one2012
Enhanced persistency of resting and active periods of locomotor activity in schizophrenia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Actigraphy studies and clinical and biobehavioural correlates in schizophrenia: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial.Scientific reports · 2016Trial
- Reduced multiscale complexity of daily behavioral dynamics in autism spectrum disorder.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats.Neurobiology of stress · 2023Article
- Neonatal phencyclidine as a model of sex-biased schizophrenia symptomatology in adolescent mice.Psychopharmacology · 2023Article
- Objective assessment of motor activity in a clinical sample of adults with attention-deficit/hyperactivity disorder and/or cyclothymic temperament.BMC psychiatry · 2022Article
- Predictive Modeling of Mental Illness Onset Using Wearable Devices and Medical Examination Data: Machine Learning Approach.Frontiers in digital health · 2022Article
- Assessing olfactory, memory, social and circadian phenotypes associated with schizophrenia in a genetic model based on Rim.Translational psychiatry · 2021Article
- CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia.Translational psychiatry · 2020Article
- Useful parameters for the motion analysis of facial skin care in Japanese women.Journal of physiological anthropology · 2020Article
- Psychomotor Slowing in Schizophrenia: Implications for Endophenotype and Biomarker Development.Biomarkers in neuropsychiatry · 2020Article
- More random motor activity fluctuations predict incident frailty, disability, and mortality.Science translational medicine · 2019Article
- Disturbed Prefrontal Cortex Activity in the Absence of Schizophrenia-Like Behavioral Dysfunction inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Assessment of Fractal Characteristics of Locomotor Activity of Geriatric In-Patients With Alzheimer's Dementia.Frontiers in aging neuroscience · 2019Article
- Capturing Rest-Activity Profiles in Schizophrenia Using Wearable and Mobile Technologies: Development, Implementation, Feasibility, and Acceptability of a Remote Monitoring Platform.JMIR mHealth and uHealth · 2018Article
- A review of physiological and behavioral monitoring with digital sensors for neuropsychiatric illnesses.Physiological measurement · 2018Review
- Expression and Function of IL-33/ST2 Axis in the Central Nervous System Under Normal and Diseased Conditions.Frontiers in immunology · 2018Review
- A Practical Guide to Analyzing Time-Varying Associations between Physical Activity and Affect Using Multilevel Modeling.Computational and mathematical methods in medicine · 2018Review
- Acoustic Hyper-Reactivity and Negatively Skewed Locomotor Activity in Children With Autism Spectrum Disorders: An Exploratory Study.Frontiers in psychiatry · 2018Article
- Dynamical state transitions into addictive behaviour and their early-warning signals.Proceedings. Biological sciences · 2017Article
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Authors and funding
8 authors.
Funding
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Abstract
Patients with schizophrenia frequently exhibit behavioral abnormalities associated with its pathological symptoms. Therefore, a quantitative evaluation of behavioral dynamics could contribute to objective diagnoses of schizophrenia. However, such an approach has not been fully established because of the absence of quantitative biobehavioral measures. Recently, we studied the dynamical properties of locomotor activity, specifically how resting and active periods are interwoven in daily life. We discovered universal statistical laws ("behavioral organization") and their alterations in patients with major depressive disorder. In this study, we evaluated behavioral organization of schizophrenic patients (n = 19) and healthy subjects (n = 11) using locomotor activity data, acquired by actigraphy, to investigate whether the laws could provide objective and quantitative measures for a possible diagnosis and assessment of symptoms. Specifically, we evaluated the cumulative distributions of resting and active periods, defined as the periods with physical activity counts successively below and above a predefined threshold, respectively. Here we report alterations in the laws governing resting and active periods; resting periods obeyed a power-law cumulative distribution with significantly lower parameter values (power-law scaling exponents), whereas active periods followed a stretched exponential distribution with significantly lower parameter values (stretching exponents), in patients. Our findings indicate enhanced persistency of both lower and higher locomotor activity periods in patients with schizophrenia, probably reflecting schizophrenic pathophysiology.
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