ArticlePloS one2012
Multiple infection and microdiversity among Helicobacter pylori isolates in a single host in India.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.PloS one · 2013Trial
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- Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori.Biology open · 2025Article
- High prevalence ofFrontiers in microbiology · 2023Article
- Prevalence of tumor necrosis factor alpha inducing protein (3 Biotech · 2021Article
- Heterogeneity ofInfection and drug resistance · 2021Article
- A Mouse Model of Helicobacter pylori Infection.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Novel virulence factorWorld journal of gastroenterology · 2020Review
- Review
- Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori.Scientific reports · 2019Article
- Genetic diversity of Escherichia coli in gut microbiota of patients with Crohn's disease discovered using metagenomic and genomic analyses.BMC genomics · 2018Article
- Recombination-independent rapid convergent evolution of the gastric pathogen Helicobacter pylori.BMC genomics · 2018Article
- Vibrio cholerae genomic diversity within and between patients.Microbial genomics · 2017Article
- Histomorphological Spectrum of Duodenal Pathology in Functional Dyspepsia Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
- Dynamic Expansion and Contraction ofmBio · 2017Article
- Genomic Microdiversity ofmBio · 2017Article
- Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori.Nature communications · 2016Article
- Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori.Genetics · 2015Article
- Article
- Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population.Gut pathogens · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori is one of the most diverse bacterial species that chronically infects more than 70% of Indian population. Interestingly, data showing microdiversity of the H. pylori strains within a particular gastric niche remained scarce. To understand the extent of genetic diversity among H. pylori strains within a given host, 30 patients with gastro-duodenal problems were subjected to endoscopy and from each patient 10 single colonies were isolated. Characterization of each of these 10 single colonies by DNA fingerprinting as well as genotyping of several important genetic markers viz. cagA, vacA, iceA, vapD, cag PAI empty site, IS605, RFLP and two other genetic segments within cag PAI revealed that all of the 30 patients were infected with more than one strain and sometimes strains with 5 to 6 types of genetic variants. Analyses of certain genetic loci showed the microdiversity among the colonies from single patient, which may be due to the recombination events during long-term carriage of the pathogen. These results suggest that most of the patients have acquired H. pylori due to repeated exposure to this pathogen with different genetic make-up, which may increase the possibility of super infections. Genetic exchanges between these unrelated H. pylori strains may support certain H. pylori variant to grow better in a given host than the parental strain and thereby increasing the possibility for the severity of the infection.
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