ArticlePloS one2012
Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis.Lipids in health and disease · 2020Pooled it
- Serum levels of adipokines in gestational diabetes: a systematic review.Journal of endocrinological investigation · 2019Pooled it
- Trial
- Omentin-1 Modulates Porcine Endometrial Steroidogenesis and Tissue Remodelling During Early Pregnancy and the Oestrous Cycle.International journal of molecular sciences · 2026Article
- The role of omentin-1 in female reproduction: a critical review.The Journal of reproduction and development · 2026Review
- Comparative analysis of inflammatory and metabolic biomarkers in PGDM and GDM pregnancies.BMC pregnancy and childbirth · 2025Article
- Plasma level of omentin-1, its expression, and its regulation by gonadotropin-releasing hormone and gonadotropins in porcine anterior pituitary cells.Scientific reports · 2023Article
- Review
- Programming of metabolism by adipokines during development.Nature reviews. Endocrinology · 2023Review
- Influence of Pre-Pregnancy Obesity on Carbohydrate and Lipid Metabolism with Selected Adipokines in the Maternal and Fetal Compartment.Nutrients · 2023Article
- New Insights into Adipokines in Gestational Diabetes Mellitus.International journal of molecular sciences · 2022Review
- Association between omentin-1 and indices of glucose metabolism in early pregnancy: a pilot study.Archives of gynecology and obstetrics · 2022Article
- Omentin-1 and its relationship with inflammatory factors in maternal plasma and visceral adipose tissue of women with gestational diabetes mellitus.Journal of endocrinological investigation · 2022Article
- Lipid dysfunction and adrenomedullin expression in omental versus subcutaneous adipose tissues in diabetic pregnancies.PloS one · 2022Article
- Emerging Protein Biomarkers for the Diagnosis or Prediction of Gestational Diabetes-A Scoping Review.Journal of clinical medicine · 2021Article
- The Role of the Adipokines in the Most Common Gestational Complications.International journal of molecular sciences · 2020Review
- Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice.Scientific reports · 2020Article
- Maternal omentin-1 level, quality of life and marital satisfaction in relation to mode of delivery: a prospective cohort study.BMC pregnancy and childbirth · 2020Article
- Adiponectin links maternal metabolism to uterine contractility.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet.Endocrine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined.
designOmentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the time of term elective Caesarean section. Omentin-1 levels were also measured in maternal plasma from 13 NGT women at 11 and 28 weeks gestation and 7 weeks postpartum.
resultsMaternal obesity was associated with significantly lower omentin-1 levels in maternal plasma; however, there was no effect of maternal obesity on cord omentin levels. Omentin-1 gene expression was lower in placenta and adipose tissue obtained from women with pre-existing obesity. In addition to this, adipose tissue release of omentin-1 was significantly lower from obese pregnant women. Omentin-1 levels were significantly lower in non-obese GDM compared to non-obese NGT women. However, there was no difference in omentin-1 levels between obese NGT and obese GDM women. There was no effect of GDM on cord omentin levels, and placental and adipose tissue omentin-1 expression. Maternal omentin-1 levels were negatively correlated with fetal birthweight and fetal ponderal index.
conclusionsThe data presented in this study demonstrate that pre-existing maternal obesity is associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. Alteration in omentin-1 in pregnancy may influence the development of metabolic disorders in offspring later in life.
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Registered trials
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