ArticlePloS one2012
Allografts of the acellular sciatic nerve and brain-derived neurotrophic factor repair spinal cord injury in adult rats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Mesenchymal Stem Cells Expressing Baculovirus-Engineered Brain-Derived Neurotrophic Factor Improve Peripheral Nerve Regeneration in a Rat Model.Tissue engineering and regenerative medicine · 2025Article
- Characterization of three washing/decellularization procedures for the production of bioactive human micronized neural tissue (hMINT).Cell and tissue banking · 2023Article
- The corticospinal tract structure of collagen/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats.Journal of materials science. Materials in medicine · 2021Article
- Single vs. Combined Therapeutic Approaches in Rats With Chronic Spinal Cord Injury.Frontiers in neurology · 2020Article
- Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.Biomedical materials (Bristol, England) · 2018Article
- Extracellular matrix based biomaterials for central nervous system tissue repair: the benefits and drawbacks.Neural regeneration research · 2017Article
- Enhancement of neural regeneration after spinal cord injury using muscle graft in experimental dogs.International journal of clinical and experimental pathology · 2017Article
- Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration.Experimental and therapeutic medicine · 2016Article
- Brain-derived neurotrophic factor promotes nerve regeneration by activating the JAK/STAT pathway in Schwann cells.Translational andrology and urology · 2016Article
- Injectable Extracellular Matrix Hydrogels as Scaffolds for Spinal Cord Injury Repair.Tissue engineering. Part A · 2016Article
- Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury(1,2,3).eNeuro · 2015Review
- A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material.BioMed research international · 2015Article
- Biomaterials for spinal cord repair.Neuroscience bulletin · 2013Review
- Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats.Neuroscience bulletin · 2013Article
- The cellular immune mechanism after transfer of chemically extracted acellular nerve xenografts.PloS one · 2013Article
- Long-term viral brain-derived neurotrophic factor delivery promotes spasticity in rats with a cervical spinal cord hemisection.Frontiers in neurology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to investigate whether an innovative growth factor-laden scaffold composed of acellular sciatic nerve (ASN) and brain-derived neurotrophic factor (BDNF) could promote axonal regeneration and functional recovery after spinal cord injury (SCI).
methodsFollowing complete transection at the thoracic level (T9), we immediately transplanted the grafts between the stumps of the severed spinal cords. We evaluated the functional recovery of the hindlimbs of the operated rats using the BBB locomotor rating scale system every week. Eight weeks after surgery, axonal regeneration was examined using the fluorogold (FG) retrograde tracing method. Electrophysiological analysis was carried out to evaluate the improvement in the neuronal circuits. Immunohistochemistry was employed to identify local injuries and recovery.
resultsThe results of the Basso-Beattie-Bresnahan (BBB) scale indicated that there was no significant difference between the individual groups. The FG retrograde tracing and electrophysiological analyses indicated that the transplantation of ASN-BDNF provided a permissive environment to support neuron regeneration.
conclusionThe ASN-BDNF transplantation provided a promising therapeutic approach to promote axonal regeneration and recovery after SCI, and can be used as part of a combinatory treatment strategy for SCI management.
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