ArticlePloS one2012
X-ray phase nanotomography resolves the 3D human bone ultrastructure.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Crossing length scales: X-ray approaches to studying the structure of biological materials.IUCrJ · 2024Review
- Deep learning to overcome Zernike phase-contrast nanoCT artifacts for automated micro-nano porosity segmentation in bone.Journal of synchrotron radiation · 2024Article
- Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering.Calcified tissue international · 2023Review
- Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review.Dentistry journal · 2023Review
- Article
- Evaluation of imaging setups for quantitative phase contrast nanoCT of mineralized biomaterials.Journal of synchrotron radiation · 2022Article
- Dose-efficient multimodal microscopy of human tissue at a hard X-ray nanoprobe beamline.Journal of synchrotron radiation · 2022Article
- Comparison of the 3D-Microstructure Between Alveolar and Iliac Bone for Enhanced Bioinspired Bone Graft Substitutes.Frontiers in bioengineering and biotechnology · 2022Article
- An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale.Scientific reports · 2021Article
- PyPhase - a Python package for X-ray phase imaging.Journal of synchrotron radiation · 2021Article
- Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography.Science advances · 2021Article
- Review
- Integrated 3D Information for Custom-Made Bone Grafts: Focus on Biphasic Calcium Phosphate Bone Substitute Biomaterials.International journal of environmental research and public health · 2020Article
- Jawbone remodeling: a conceptual study based on Synchrotron High-resolution Tomography.Scientific reports · 2020Article
- X-ray computed tomography in life sciences.BMC biology · 2020Review
- Review
- Next-generation imaging of the skeletal system and its blood supply.Nature reviews. Rheumatology · 2019Review
- Biomechanical behaviours of the bone-implant interface: a review.Journal of the Royal Society, Interface · 2019Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone strength and failure are increasingly thought to be due to ultrastructural properties, such as the morphology of the lacuno-canalicular network, the collagen fiber orientation and the mineralization on the nanoscale. However, these properties have not been studied in 3D so far. Here we report the investigation of the human bone ultrastructure with X-ray phase nanotomography, which now provides the required sensitivity, spatial resolution and field of view. The 3D organization of the lacuno-canalicular network is studied in detail over several cells in osteonal and interstitial tissue. Nanoscale density variations are revealed and show that the cement line separating these tissues is hypermineralized. Finally, we show that the collagen fibers are organized as a twisted plywood structure in 3D.
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