ArticleFrontiers in genetics2012
Genes contributing to genetic variation of muscling in sheep.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.Animal genetics · 2026Review
- Parent-of-origin effects in sheep: impact on the data fit, explanatory power of the model and theoretical accuracy of the breeding values.Scientific reports · 2026Article
- The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep.Animals : an open access journal from MDPI · 2024Article
- Remarkable chromosomes and karyotypes: A top 10 list.Molecular biology of the cell · 2024Review
- Recent advances in the genomic resources for sheep.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Effects of Dam and Sire Breeds on Lamb Carcass Quality and Composition in Pasture-Based Systems.Animals : an open access journal from MDPI · 2023Article
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- Optimized Cas9:sgRNA delivery efficiently generates biallelic MSTN knockout sheep without affecting meat quality.BMC genomics · 2022Article
- Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep.Tropical animal health and production · 2022Article
- Generation of Double-Muscled Sheep and Goats by CRISPR /Cas9-Mediated Knockout of the Myostatin Gene.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Growth performance and meat characteristics of the first filial Awassi-Rambouillet callipyge ram lambs.Veterinary world · 2019Article
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- Study on the transcriptional regulatory mechanism of the MyoD1 gene in Guanling bovine.RSC advances · 2018Article
- Effects and interactions of myostatin and callipyge mutations: I. Growth and carcass traits.Journal of animal science · 2018Article
- A high resolution atlas of gene expression in the domestic sheep (Ovis aries).PLoS genetics · 2017Article
- Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle.Scientific reports · 2017Article
- Effects of different dietary inclusion levels of macadamia oil cake on growth performance and carcass characteristics in South African mutton merino lambs.Tropical animal health and production · 2017Article
- The distribution of runs of homozygosity and selection signatures in six commercial meat sheep breeds.PloS one · 2017Article
- Detailed phenotyping identifies genes with pleiotropic effects on body composition.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality, and reproductive efficiency. Natural mutations in sheep that enhance muscling have been identified, while a number of genome scans have identified and confirmed quantitative trait loci (QTL) for skeletal muscle traits. The detailed phenotypic characteristics of sheep carrying these mutations or QTL affecting skeletal muscle show a number of common biological themes, particularly changes in developmental growth trajectories, alterations of whole animal morphology, and a shift toward fast twitch glycolytic fibers. The genetic, developmental, and biochemical mechanisms underpinning the actions of some of these genetic variants are described. This review critically assesses this research area, identifies gaps in knowledge, and highlights mechanistic linkages between genetic polymorphisms and skeletal muscle phenotypic changes. This knowledge may aid the discovery of new causal genetic variants and in some cases lead to the development of biochemical and immunological strategies aimed at enhancing skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.