ArticleFrontiers in molecular neuroscience2012
Locomotor sensitization to EtOH: contribution of β-Endorphin.
Article in Frontiers in molecular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice.Addiction neuroscience · 2025Article
- The Protective Effects of Water Extracts of Compound Turmeric Recipe on Acute Alcoholism: An Experimental Research Using a Mouse Model.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Neuroplastic changes in addiction.Frontiers in molecular neuroscience · 2014Article
- Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde.Frontiers in behavioral neuroscience · 2013Article
- Long-term consequences of developmental alcohol exposure on brain structure and function: therapeutic benefits of physical activity.Brain sciences · 2012Article
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Authors and funding
2 authors.
Funding
Abstract
Alcohol use disorders, like all drug addictions, involve a constellation of adaptive changes throughout the brain. Neural activity underlying changes in the rewarding properties of alcohol reflect changes in dopamine transmission in mesolimbic and nigrostriatal pathways and these effects are modulated by endogenous opioids such as β-Endorphin. In order to study the role of β-Endorphin in the development of locomotor sensitization to repeated EtOH exposure, we tested transgenic mice that vary in their capacity to synthesize this peptide as a result of constitutive modification of the Pomc gene. Our results indicate that mice deficient in β-Endorphin show attenuated locomotor activation following an acute injection of EtOH (2.0 g/kg) and, in contrast to wildtype mice, fail to demonstrate locomotor sensitization after 12 days of repeated EtOH injections. These data support the idea that β-Endorphin modulates the locomotor effects of EtOH and contributes to the neuroadaptive changes associated with chronic use.
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Registered trials
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