Evidence map›Paper›PMID 22952391›Full record

ReviewCold Spring Harbor perspectives in biology2012

Treg cells, life history, and diversity.

Christophe Benoist, Diane Mathis

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 136 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
    Review
  5. Article
  6. Article
  7. An integrated transcription factor framework for Treg identity and diversity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
  9. T Cell Subsets and Immune Homeostasis.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. Article
  11. Regulatory T cells in allergic inflammation.Seminars in immunology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. CPHEN-016: Comprehensive phenotyping of human regulatory T cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022
    Article
  16. Developmentally distinct CD4Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Loss of 15-lipoxygenase disrupts TCell death and differentiation · 2021
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christophe BenoistDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Diane Mathis
Harvard University · US

Funding

Adipose-tissue Tregs: important players in immunological control of metabolismR01DK092541 · NIDDK · HARVARD MEDICAL SCHOOL · PI DIANE J MATHIS · 2011 to 2026
$6.4M
Naive T cell survival: TCR and IL-7R signal interplayR01AI051530 · NIAID · JOSLIN DIABETES CENTER · PI BENOIST, CHRISTOPHE O. · 2002 to 2009
$2.4M
NIAID NIH HHS R01 AI051530NIAID NIH HHS R01-AI51530NIDDK NIH HHS R01 DK092541NIDDK NIH HHS R01-DK92541
6 · The paper itself

Abstract

Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.

Indexed as

AnimalsCell DifferentiationCell LineageForkhead Transcription FactorsHumansImmune TolerancePhenotypeT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, human

Identifiers

PMID22952391
PMCPMC3428763
OpenAlexW2068560430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.