Evidence map›Paper›PMID 22951919›Full record

ReviewBiotechnology advances

Shining light on nanotechnology to help repair and regeneration.

Asheesh Gupta, Pinar Avci, Magesh Sadasivam, Rakkiyappan Chandran, Nivaldo Parizotto, Daniela Vecchio, Wanessa C M A de Melo, Tianhong Dai, Long Y Chiang, Michael R Hamblin

Abstract readReview
In one paragraph

Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Low-level laser therapy improves the VOLasers in medical science · 2018
    Trial
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. [Research progress of infrared light promoting wound healing].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. [Intense pulsed light (IPL) as a therapeutic option for Meibomian gland dysfunction].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Asheesh GuptaWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Pinar Avci
Magesh Sadasivam
Rakkiyappan Chandran
Nivaldo Parizotto
Daniela Vecchio
Wanessa C M A de Melo
Tianhong Dai
Long Y Chiang
Michael R Hamblin
Massachusetts General Hospital · USHarvard University · USAmity University · INHarvard–MIT Division of Health Sciences and Technology · USUniversidade Federal de São Carlos · BRUniversity of Massachusetts Lowell · US

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
New Stereoregular Functionalized Fullerenes as Nanomedicines for PDTR01CA137108 · NCI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI CHIANG, LONG Y. · 2009 to 2012
$1.3M
NCI NIH HHS R01 CA137108NCI NIH HHS R01CA137108NIAID NIH HHS R01 AI050875NIAID NIH HHS R01AI050875
6 · The paper itself

Abstract

Phototherapy can be used in two completely different but complementary therapeutic applications. While low level laser (or light) therapy (LLLT) uses red or near-infrared light alone to reduce inflammation, pain and stimulate tissue repair and regeneration, photodynamic therapy (PDT) uses the combination of light plus non-toxic dyes (called photosensitizers) to produce reactive oxygen species that can kill infectious microorganisms and cancer cells or destroy unwanted tissue (neo-vascularization in the choroid, atherosclerotic plaques in the arteries). The recent development of nanotechnology applied to medicine (nanomedicine) has opened a new front of advancement in the field of phototherapy and has provided hope for the development of nanoscale drug delivery platforms for effective killing of pathological cells and to promote repair and regeneration. Despite the well-known beneficial effects of phototherapy and nanomaterials in producing the killing of unwanted cells and promoting repair and regeneration, there are few reports that combine all three elements i.e. phototherapy, nanotechnology and, tissue repair and regeneration. However, these areas in all possible binary combinations have been addressed by many workers. The present review aims at highlighting the combined multi-model applications of phototherapy, nanotechnology and, reparative and regeneration medicine and outlines current strategies, future applications and limitations of nanoscale-assisted phototherapy for the management of cancers, microbial infections and other diseases, and to promote tissue repair and regeneration.

Indexed as

AnimalsHumansNanomedicinePhotochemotherapyPhototherapyRegenerationRegenerative Medicine

Identifiers

PMID22951919
PMCPMC3528806
OpenAlexW2012480737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.