Evidence map›Paper›PMID 22951477›Full record

ReviewHealth physics2012

X-ray fluorescence microscopy for investigation of archival tissues.

T Paunesku, M B Wanzer, E N Kirillova, K N Muksinova, V S Revina, E R Lyubchansky, B Grosche, M Birschwilks, S Vogt, L Finney and 1 more

Abstract readReview
In one paragraph

Review in Health physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
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  4. Single-cell visualization and quantification of trace metals inProceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

T PauneskuFeinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward 13-007, Chicago, IL 60611, USA.
M B Wanzer
E N Kirillova
K N Muksinova
V S Revina
E R Lyubchansky
B Grosche
M Birschwilks
S Vogt
L Finney
G E Woloschak
Institute of Biophysics · RUFederal Office for Radiation Protection · DENorthwestern University · US

Funding

X-RAY STUDIES OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE BRAIN TISSUEP41RR008630 · NCRR · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2001 to 2011
$14.4M
Theranostic Magnetic Nanostructures for the Molecular Imaging of CancerU54CA151880 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MEADE, THOMAS J · 2010 to 2014
$11.5M
Nanoprobe for High Resolution Hard X-ray Fluorescence MicroscopyS10RR029272 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2010 to 2010
$2.9M
Applications of TiO2-DNA nanocompositesR01EB002100 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2005 to 2013
$2.5M
Application of TiO2-DNA nanocomposites to Cancer CellsR01CA107467 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2004 to 2006
$960k
NCI NIH HHS R01 CA107467NCI NIH HHS U54 CA151880NCRR NIH HHS P41 RR008630NCRR NIH HHS S10 RR029272NIBIB NIH HHS R01 EB002100
6 · The paper itself

Abstract

Several recent efforts in the radiation biology community worldwide have amassed records and archival tissues from animals exposed to different radionuclides and external beam irradiation. In most cases, these samples come from lifelong studies on large animal populations conducted in national laboratories and equivalent institutions throughout Europe, North America, and Japan. While many of these tissues were used for histopathological analyses, much more information may still be obtained from these samples. A new technique suitable for imaging of these tissues is x-ray fluorescence microscopy (XFM). Following development of third generation synchrotrons, XFM has emerged as an ideal technique for the study of metal content, speciation, and localization in cells, tissues, and organs. Here the authors review some of the recent XFM literature pertinent to tissue sample studies and present examples of XFM data obtained from tissue sections of beagle dog samples, which show that the quality of archival tissues allows XFM investigation.

Indexed as

Tissue PreservationAnimalsHumansMicroscopy, FluorescenceX-Rays

Identifiers

PMID22951477
PMCPMC3716449
OpenAlexW1727395646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.