Evidence map›Paper›PMID 22951405›Full record

ArticlePlant signaling & behavior2012

Arabidopsis scaffold protein RACK1A modulates rare sugar D-allose regulated gibberellin signaling.

Herman Fennell, Abdulquadri Olawin, Rahman M Mizanur, Ken Izumori, Jin-Gui Chen, Hemayet Ullah

Open access · bronzeAbstract read
In one paragraph

Article in Plant signaling & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Herman FennellDepartment of Biology, Howard University, Washington, DC, USA.
Abdulquadri Olawin
Rahman M Mizanur
Ken Izumori
Jin-Gui Chen
Hemayet Ullah
Howard University · USKagawa University · JPOak Ridge National Laboratory · USUnited States Army Medical Research and Development Command · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As energy sources and structural components, sugars are the central regulators of plant growth and development. In addition to the abundant natural sugars in plants, more than 50 different kinds of rare sugars exist in nature, several of which show distinct roles in plant growth and development. Recently, one of the rare sugars, D-allose, an epimer of D-glucose at C3, is found to suppress plant hormone gibberellin (GA) signaling in rice. Scaffold protein RACK1A in the model plant Arabidopsis is implicated in the GA pathway as rack1a knockout mutants show insensitivity to GA in GA-induced seed germination. Using genetic knockout lines and a reporter gene, the functional role of RACK1A in the D-allose pathway was investigated. It was found that the rack1a knockout seeds showed hypersensitivity to D-allose-induced inhibition of seed germination, implicating a role for RACK1A in the D-allose mediated suppression of seed germination. On the other hand, a functional RACK1A in the background of the double knockout mutations in the other two RACK1 isoforms, rack1b/rack1c, showed significant resistance to the D-allose induced inhibition of seed germination. The collective results implicate the RACK1A in the D-allose mediated seed germination inhibition pathway. Elucidation of the rare sugar signaling mechanism will help to advance understanding of this less studied but important cellular signaling pathway.

Indexed as

ArabidopsisArabidopsis ProteinsGene Expression Regulation, PlantGerminationGibberellinsGlucosePlants, Genetically ModifiedReceptors, Cell SurfaceReceptors for Activated C KinaseSeedsalloseArabidopsis ProteinsGibberellinsGlucoseRACK1 protein, ArabidopsisReceptors, Cell SurfaceReceptors for Activated C KinaseArabidopsiscell signalingD-allosegerminationgibberellinRACK1rare sugarscaffold protein

Identifiers

PMID22951405
PMCPMC3548859
OpenAlexW2037637932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.