ArticlePlant signaling & behavior2012
Identification of two-component system elements downstream of AHK5 in the stomatal closure response of Arabidopsis thaliana.
Article in Plant signaling & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Integrative approaches for the structure-based functional understanding of the ethylene response in plants.The Plant journal : for cell and molecular biology · 2026Review
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- ARR1 and AHP interactions in the multi-step phosphorelay system.Frontiers in plant science · 2025Article
- Identification of the AHP family reveals their critical response to cytokinin regulation during adventitious root formation in apple rootstock.Frontiers in plant science · 2024Article
- Improving Performance of Salt-Grown Crops by Exogenous Application of Plant Growth Regulators.Biomolecules · 2021Review
- Ectopic expression of GmHP08 enhances resistance of transgenic Arabidopsis toward drought stress.Plant cell reports · 2021Article
- The Interaction Network and Signaling Specificity of Two-Component System inInternational journal of molecular sciences · 2020Review
- Ethylene signaling in plants.The Journal of biological chemistry · 2020Review
- Histidine kinase MHZ1/OsHK1 interacts with ethylene receptors to regulate root growth in rice.Nature communications · 2020Article
- New Insight into HPts as Hubs in Poplar Cytokinin and Osmosensing Multistep Phosphorelays: Cytokinin Pathway Uses Specific HPts.Plants (Basel, Switzerland) · 2019Article
- New Insights into Multistep-Phosphorelay (MSP)/ Two-Component System (TCS) Regulation: Are Plants and Bacteria that Different?Plants (Basel, Switzerland) · 2019Review
- Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes.Genome biology and evolution · 2019Article
- What do archaeal and eukaryotic histidine kinases sense?F1000Research · 2019Review
- A role for two-component signaling elements in the Arabidopsis growth recovery response to ethylene.Plant direct · 2018Article
- Arabidopsis CKI1 mediated two-component signaling in the specification of female gametophyte.Plant signaling & behavior · 2018Article
- Techniques for the Analysis of Protein-Protein Interactions in Vivo.Plant physiology · 2016Review
- Transcriptomic network analyses of leaf dehydration responses identify highly connected ABA and ethylene signaling hubs in three grapevine species differing in drought tolerance.BMC plant biology · 2016Article
- Arabidopsis type B cytokinin response regulators ARR1, ARR10, and ARR12 negatively regulate plant responses to drought.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Transcriptome Analysis of Chilling-Imbibed Embryo Revealed Membrane Recovery Related Genes in Maize.Frontiers in plant science · 2016Article
- Protein phosphorylation in stomatal movement.Plant signaling & behavior · 2014Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To optimize water use efficiency, plants regulate stomatal closure through a complex signaling process. Hydrogen peroxide (H₂O₂) is produced in response to several environmental stimuli, and has been identified as a key second messenger involved in the regulation of stomatal aperture. The Arabidopsis histidine kinase 5 (AHK5) has been shown to regulate stomatal closure in response to H₂O₂ and other stimuli that depend on H₂O₂. AHK5 is a member of the two-component system (TCS) in Arabidopsis. The plant TCS comprises three different protein types: the hybrid histidine kinases (HKs), the phosphotransfer proteins (HPs) and the response regulators (RRs). Here we determined TCS elements involved in H₂O₂- and ethylene-dependent stomatal closure downstream of AHK5. By yeast and in planta interaction assays and functional studies, AHP1, 2 and 5 as well as the response regulators ARR4 and ARR7 were identified acting downstream of AHK5 in the ethylene and H₂O₂ response pathways of guard cells. Furthermore, we demonstrate that aspartate phosphorylation of ARR4 is only required for the H₂O₂- but not for the ethylene-induced stomatal closure response. Our data suggest the presence of a complex TCS signaling network comprising of at least AHK5, several AHPs and response regulators, which modulate stomatal closure in response to H₂O₂ and ethylene.
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