ArticleJournal of the Royal Society, Interface2012
Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026Review
- Beyond Killing: The Overlooked Contribution of Neutrophils to Tissue Repair.International journal of molecular sciences · 2025Review
- Article
- Neutrophil reverse migration.Journal of inflammation (London, England) · 2022Review
- Wound Healing Insights from Flies and Fish.Cold Spring Harbor perspectives in biology · 2022Review
- Deletion ofFrontiers in immunology · 2020Article
- Live Imaging of Heart Injury in Larval Zebrafish Reveals a Multi-Stage Model of Neutrophil and Macrophage Migration.Frontiers in cell and developmental biology · 2020Article
- The SIPHER Consortium: Introducing the new UK hub for systems science in public health and health economic research.Wellcome open research · 2019Article
- The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish.Frontiers in immunology · 2019Article
- Article
- Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.Cell reports · 2017Article
- Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient.Current biology : CB · 2016Article
- Neutrophil migration in infection and wound repair: going forward in reverse.Nature reviews. Immunology · 2016Review
- Cox process representation and inference for stochastic reaction-diffusion processes.Nature communications · 2016Article
- Simulation-based Bayesian Analysis of Complex Data.Summer Computer Simulation Conference : (SCSC 2015) : 2015 Summer Simulation Multi-Conference (SummerSim'15) : Chicago, Illinois, USA, 26-29 July 2015. Summer Computer Simulation Conference (2015 : Chicago, Illinois) · 2015Article
- Defining the phenotype of neutrophils following reverse migration in zebrafish.Journal of leukocyte biology · 2015Article
- Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus.PLoS pathogens · 2015Article
- Inflammatory triggers of acute rejection of organ allografts.Immunological reviews · 2014Review
- A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.Science translational medicine · 2014Article
- Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels.Integrative biology : quantitative biosciences from nano to macro · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Following neutralization of infectious threats, neutrophils must be removed from inflammatory sites for normal tissue function to be restored. Recently, a new paradigm has emerged, in which viable neutrophils migrate away from inflammatory sites by a process best described as reverse migration. It has generally been assumed that this process is the mirror image of chemotaxis, where neutrophils are drawn into the areas of infection or tissue damage by gradients of chemotactic cues. Indeed, efforts are underway to identify cues that drive neutrophils away by the reverse process, fugetaxis. By using photoconvertible pigments expressed in neutrophils in transparent zebrafish larvae, we were able to image the position of each neutrophil during inflammation resolution in vivo. These neutrophil coordinates were analysed within a dynamic modelling framework, using different forms of the drift-diffusion equation with model selection and parameter estimation based on approximate Bayesian computation. This analysis revealed the experimental data were best fitted by a model incorporating a diffusion term but no drift term-where the presence of drift would indicate fugetaxis. This result, for the first time, provides rigorous data-driven evidence that reverse migration of neutrophils in vivo is not a form of fugetaxis, but rather a stochastic redistribution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.