ArticleCell calcium2012
Developmental profile of localized spontaneous Ca(2+) release events in the dendrites of rat hippocampal pyramidal neurons.
Article in Cell calcium, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Calmodulin controls spatial and temporal specificity of calcium-induced calcium release.PLoS computational biology · 2026Article
- Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons.Biomolecules · 2024Review
- Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory.Communications biology · 2022Article
- The spatio-temporal properties of calcium transients in hippocampal pyramidal neuronsFrontiers in cellular neuroscience · 2022Article
- Article
- Mapping of excitatory and inhibitory postsynaptic potentials of neuronal populations in hippocampal slices using the GEVI, ArcLight.Journal of physics D: Applied physics · 2018Article
- Voltage imaging to understand connections and functions of neuronal circuits.Journal of neurophysiology · 2016Review
- Spindle Activity Orchestrates Plasticity during Development and Sleep.Neural plasticity · 2016Review
- Imaging with organic indicators and high-speed charge-coupled device cameras in neurons: some applications where these classic techniques have advantages.Neurophotonics · 2015Review
- Article
- Dendritic calcium nonlinearities switch the direction of synaptic plasticity in fast-spiking interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons.Journal of neurophysiology · 2014Article
- Ca2+ sparks and puffs are generated and interact in rat hippocampal CA1 pyramidal neuron dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Understanding calcium waves and sparks in central neurons.Nature reviews. Neuroscience · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent experiments demonstrate that localized spontaneous Ca(2+) release events can be detected in the dendrites of pyramidal cells in the hippocampus and other neurons (J. Neurosci. 29 (2009) 7833-7845). These events have some properties that resemble ryanodine receptor mediated "sparks" in myocytes, and some that resemble IP(3) receptor mediated "puffs" in oocytes. They can be detected in the dendrites of rats of all tested ages between P3 and P80 (with sparser sampling in older rats), suggesting that they serve a general signaling function and are not just important in development. However, in younger rats the amplitudes of the events are larger than the amplitudes in older animals and almost as large as the amplitudes of Ca(2+) signals from backpropagating action potentials (bAPs). The rise time of the event signal is fast at all ages and is comparable to the rise time of the bAP fluorescence signal at the same dendritic location. The decay time is slower in younger animals, primarily because of weaker Ca(2+) extrusion mechanisms at that age. Diffusion away from a brief localized source is the major determinant of decay at all ages. A simple computational model closely simulates these events with extrusion rate the only age dependent variable.
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