Trial reportDrug and alcohol dependence2013
Epidemiology of pain among outpatients in methadone maintenance treatment programs.
Trial report in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Mental Health Distress Is Associated With Higher Pain Interference in Patients With Opioid Use Disorder Stabilized on Buprenorphine or Methadone.Substance use & addiction journal · 2024Trial
- An evaluation of the feasibility, acceptability, and preliminary efficacy of cognitive-behavioral therapy for opioid use disorder and chronic pain.Drug and alcohol dependence · 2019Trial
- Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).PloS one · 2017Trial
- Longitudinal association between pain severity and subsequent opioid use in prescription opioid dependent patients with chronic pain.Drug and alcohol dependence · 2016Trial
- Reasons for opioid use among patients with dependence on prescription opioids: the role of chronic pain.Journal of substance abuse treatment · 2014Trial
- Associations Between Pain Severity and Opioid Agonist Treatment Among People With Drug Injection Experience in Australia.Drug and alcohol review · 2026Article
- Pain assessment tools in patients with substance use disorders: a systematic scoping review.Addiction science & clinical practice · 2026Article
- Optimizing Opioid Use in Pain Management: A Comprehensive Review of Clinical Benefits, Risks, and Dependence.Healthcare (Basel, Switzerland) · 2026Review
- Change in self-reported somatic symptoms among patients in opioid maintenance treatment from baseline to 1-year follow-up.BMC psychiatry · 2024Article
- Accessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures.JAMA network open · 2024Article
- Association between recent overdose and chronic pain among individuals in treatment for opioid use disorder.PloS one · 2022Article
- Problematic Opioid Use: A Scoping Literature Review of Profiles.Substance abuse : research and treatment · 2022Article
- Craving mediates the association between momentary pain and illicit opioid use during treatment for opioid-use disorder: an ecological momentary assessment study.Addiction (Abingdon, England) · 2021Observational
- Psychological Flexibility, Pain Characteristics and Risk of Opioid Misuse in Noncancerous Chronic Pain Patients.Journal of clinical psychology in medical settings · 2021Article
- Psychiatric comorbidity and order of condition onset among patients seeking treatment for chronic pain and opioid use disorder.Drug and alcohol dependence · 2021Article
- Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients.Frontiers in psychiatry · 2021Article
- Alexithymia and pain experience among patients using methadone-maintenance therapy.Drug and alcohol dependence · 2021Article
- Motivations to initiate injectable hydromorphone and diacetylmorphine treatment: A qualitative study of patient experiences in Vancouver, Canada.The International journal on drug policy · 2020Article
- Understanding the relapse process: exploring Iranian women's substance use experiences.Substance abuse treatment, prevention, and policy · 2019Article
- Self-Rated Physical Health and Unmet Healthcare Needs among Swedish Patients in Opioid Substitution Treatment.Journal of addiction · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundThis analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT).
methodsPatients in two MMT programs starting a hepatitis care coordination randomized controlled trial completed the Brief Pain Inventory Short-Form and other questionnaires. Associations between clinically significant pain (average daily pain≥5 or mean pain interference≥5 during the past week) and sociodemographic data, medical status, depressive symptoms, and health-related quality of life, and current substance use were evaluated in multivariate analyses.
resultsThe 489 patients included 31.8% women; 30.3% Hispanics, 29.4% non-Hispanic Blacks, and 36.0% non-Hispanic Whites; 60.1% had hepatitis C, 10.6% had HIV, and 46.8% had moderate or severe depressive symptomatology. Mean methadone dose was 95.7mg (SD 48.9) and urine drug screening (UDS) was positive for opiates, cocaine, and amphetamines in 32.9%, 40.1%, and 2.9%, respectively. Overall, 237 (48.5%) reported clinically significant pain. Pain treatments included prescribed opioids (38.8%) and non-opioids (48.9%), and self-management approaches (60.8%), including prayer (33.8%), vitamins (29.5%), and distraction (12.7%). Pain was associated with higher methadone dose, more medical comorbidities, prescribed opioid therapy, and more severe depressive symptomatology; it was not associated with UDS or self-reported substance use.
conclusionsClinically significant pain was reported by almost half of the patients in MMT programs and was associated with medical and psychological comorbidity. Pain was often treated with opioids and was not associated with measures of drug use. Studies are needed to further clarify these associations and determine their importance for pain treatment strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.