ArticleBMC cancer2012
Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract.
Article in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Electronic patient-reported outcome systems and capabilities in cancer care: a systematic review.Frontiers in digital health · 2025Pooled it
- Advancing patient-centered cancer care: a systematic review of electronic patient-reported outcome measures.Frontiers in rehabilitation sciences · 2024Pooled it
- Pooled it
- Effects of intensive physiotherapy on Quality of Life (QoL) after pancreatic cancer resection: a randomized controlled trial.BMC cancer · 2022Trial
- Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer.Cancer immunology, immunotherapy : CII · 2014Trial
- Development of the natural history component of an early economic model for primary sclerosing cholangitis.Orphanet journal of rare diseases · 2025Article
- Evaluating the relationship between patient activation and health-related quality of life (HRQOL) in patients with pancreatic cancer (PwPC).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- The Appropriate First-Line Chemotherapy Regimen for Incurable Pancreatic Cancer in Clinical Practice: A Consideration of Patients' Overall Survival and Quality of Life.Journal of pancreatic cancer · 2021Article
- A Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies.Chemical senses · 2021Review
- Prevalence and severity of long-term physical, emotional, and cognitive fatigue across 15 different cancer entities.Cancer medicine · 2020Article
- Effects of Counselling on Quality of Life among Cancer Patients in Malaysia: A Randomized Controlled Trial.Iranian journal of public health · 2020Article
- Treatment and survival rates of stage IV pancreatic cancer at VA hospitals: a nation-wide study.Journal of gastrointestinal oncology · 2019Article
- Association of time interval between cancer diagnosis and initiation of palliative chemotherapy with overall survival in patients with unresectable pancreatic cancer.Cancer medicine · 2019Article
- Determinants of quality of life among Malaysian cancer patients: a cross-sectional study.Health and quality of life outcomes · 2018Article
- Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL.Cell death & disease · 2017Article
- β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice.PLoS genetics · 2017Article
- Pancreatic cancer survivors' preferences, barriers, and facilitators related to physical activity and diet interventions.Journal of cancer survivorship : research and practice · 2016Article
- Quality of life across chemotherapy lines in patients with advanced colorectal cancer: a prospective single-center observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Observational
- Quality of life in cancer patients undergoing chemotherapy in a tertiary care center in malwa region of punjab.Indian journal of palliative care · 2014Article
- New and emerging treatment options for biliary tract cancer.OncoTargets and therapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with cancers of the pancreatic and biliary tract quality of life (QOL) improvement is the main treatment goal, since survival can be prolonged only marginally. Up to date, knowledge on QOL impairments throughout the entire treatment process, often including several chemotherapy lines, is scarce. Our study aimed at investigating QOL trajectories from adjuvant treatment to palliative 3rd-line therapy
methodsPatients were included in routine electronic patient-reported outcome monitoring at Kufstein County Hospital at the time of diagnosis and assessed with the EORTC QLQ-C30 during each chemotherapy cycle.
resultsEighty out of 147 patients with pancreatic cancer or cancer of the bile ducts treated at the Kufstein County Hospital, fulfilled inclusion criteria and could be included in the study (mean age 67.4 years; 53.8% women). Physical, Emotional and Cognitive Functioning, and Global QOL deteriorated across chemotherapy lines, whereas Fatigue, Pain, Dyspnoea, Sleeping Disturbances, Diarrhoea, and Taste Alterations increased. With regard to Physical Functioning, Global QOL, Fatigue, Dyspnoea, Diarrhoea and Taste Alterations, the patients receiving adjuvant or 1st-line palliative chemotherapy did not differ significantly. Most patients in 2nd- or 3rd-line chemotherapy showed significantly higher impairments and symptom burden. However, patients under 1st and 2nd-line treatment showed stable QOL trajectories, whereas 3rd-line patients perceived substantial deteriorations.
conclusionsThe results suggest early palliative treatment initiation to stabilise QOL on a level as high as possible. The continuous QOL improvement during adjuvant treatment, probably reflecting post-operative recovery, may indicate that deleterious effects of adjuvant chemotherapy on QOL are highly unlikely.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.