Trial reportJournal of alternative and complementary medicine (New York, N.Y.)2012
Effect of acupuncture therapy for postponing Wallerian degeneration of cerebral infarction as shown by diffusion tensor imaging.
Trial report in Journal of alternative and complementary medicine (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02457039 (An Assessor-Blinded, Randomised Controlled Trial of Acupuncture to Prevent Chemobrain in Breast Cancer Patients), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Assessor-Blinded, Randomised Controlled Trial of Acupuncture to Prevent Chemobrain in Breast Cancer Patients
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Head Acupuncture Plus Schuell's Language Rehabilitation for Post-Stroke Aphasia: A Systematic Review and Meta-Analysis of 32 Randomized Controlled Trials.Chinese journal of integrative medicine · 2022Pooled it
- Acupuncture for cognitive functions in post-COVID-19 condition: study protocol of a three-armed, randomized controlled trial with multimodal MRI.Frontiers in medicine · 2026Article
- Review
- Traumatic Brain Injury: Acupuncture Treatment.Medical acupuncture · 2023Article
- Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI.Neural plasticity · 2021Review
- Predictors for the use of traditional Chinese medicine among inpatients with first-time stroke: a population-based study.BMC complementary medicine and therapies · 2020Article
- Acupuncture Enhances Communication between Cortices with Damaged White Matters in Poststroke Motor Impairment.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Role of Acupuncture in the Management of Severe Acquired Brain Injuries (sABIs).Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Mechanisms of Acupuncture Therapy for Cerebral Ischemia: an Evidence-Based Review of Clinical and Animal Studies on Cerebral Ischemia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Review
- Diffusional kurtosis imaging in evaluating the secondary change of corticospinal tract after unilateral cerebral infarction.American journal of translational research · 2017Article
- White matter injury in ischemic stroke.Progress in neurobiology · 2016Review
- The Status of the Quality Control in Acupuncture-Neuroimaging Studies.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Actigraph evaluation of acupuncture for treating restless legs syndrome.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Molecular imaging in traditional Chinese medicine therapy for neurological diseases.BioMed research international · 2013Review
- Brain connectivity plasticity in the motor network after ischemic stroke.Neural plasticity · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOne aim of this study was to investigate the effects of acupuncture on cerebral function of patients with acute cerebral infarction. Another goal was to evaluate the relationship between acupuncture treatment and motor recovery patients with stroke and to provide a foundation for using acupuncture therapy for such patients.
designTwenty (20) patients with recent cerebral infarction were divided randomly to an acupuncture group and a control group. The infarction area in each patient was in the basal ganglia or included the basal ganglia with an area size of > 1 cm(2). Serial diffusion tensor imaging (DTI), fluid-attenuated inversion recovery (FLAIR), and T2-weighted imaging (T(2)WI) scans were performed on all patients and the results were evaluated using the National Institute of Health Stroke Scale and the Barthel Index each week. DTI images were postprocessed and analyzed. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of abnormal signals on DTI in the infarction areas and cerebral peduncles were calculated for both groups and compared with one another.
results(1) The ADC value of infarction lesions decreased at stroke onset; then, a significant elevation was observed after the acute stage, and a significant reduction in FA values was observed from stroke onset to the chronic stage. (2) The ADC of the bilateral cerebral peduncle was reduced on the infarction side. (3) There was a significant difference in ADC and FA values between the acupuncture and control groups. The FA value was higher in the acupuncture group than the control group.
conclusionsADC and FA values might correlate to patient recovery and reveal the progress of secondary degeneration. Acupuncture treatment is effective for protecting neurons and facilitating recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.