Trial reportBMC women's health2012
Cryo-thawed embryo transfer: natural versus artificial cycle. A non-inferiority trial. (ANTARCTICA trial).
Trial report in BMC women's health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Natural cycle in vitro fertilisation (IVF) for subfertile couples.The Cochrane database of systematic reviews · 2013Pooled it
- Reproductive outcomes of vitrified blastocyst transfer in modified natural cycle versus mild hormonally stimulated and artificial protocols: A randomized control trial.JBRA assisted reproduction · 2018Trial
- HCG administration after endogenous LH rise negatively influences pregnancy rate in modified natural cycle for frozen-thawed euploid blastocyst transfer: a pilot study.Journal of assisted reproduction and genetics · 2018Trial
- A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer.Human reproduction (Oxford, England) · 2016Trial
- Evaluating the role of GnRH agonists in frozen embryo transfer cycles among polycystic ovary syndrome patients: a randomized clinical trial.Annals of medicine and surgery (2012) · 2026Article
- Effect of Low-Dose Estradiol on the Clinical Pregnancy Rate of the Hormone Replacement Frozen-Thawed Embryo Transfer Cycle.International journal of women's health · 2026Article
- The relationship between dominant follicle development and clinical outcomes of hormone replacement therapy-frozen embryo transfer: a retrospective clinical study.Frontiers in endocrinology · 2023Article
- Assessment of progesterone levels on the day of pregnancy test determination: A novel concept toward individualized luteal phase support.Frontiers in endocrinology · 2023Article
- The relationship between serum oestrogen levels and clinical outcomes of hormone replacement therapy-frozen embryo transfer: a retrospective clinical study.BMC pregnancy and childbirth · 2022Article
- Alterations of miR-16, miR-let-7a and their target genes expression in human blastocysts following vitrification and re-vitrification.Reproductive biology and endocrinology : RB&E · 2021Article
- The exact synchronization timing between the cleavage embryo stage and duration of progesterone therapy-improved pregnancy rates in frozen embryo transfer cycles: A cross-sectional study.International journal of reproductive biomedicine · 2021Article
- Current Therapeutic Options for Controlled Ovarian Stimulation in Assisted Reproductive Technology.Drugs · 2020Review
- Effects of artificial cycles with and without gonadotropin-releasing hormone agonist pretreatment on frozen embryo transfer outcomes.The Journal of international medical research · 2020Article
- Efficacy of four vaginal progesterones for luteal phase support in frozen-thawed embryo transfer cycles: A randomized clinical trial.Reproductive medicine and biology · 2020Article
- Natural cycle versus artificial cycle in frozen-thawed embryo transfer: A randomized prospective trial.Turkish journal of obstetrics and gynecology · 2018Article
- Modified natural cycle frozen-thawed embryo transfer in patients with repeated implantation failure: An observational study.International journal of reproductive biomedicine · 2016Article
- Methods for endometrial preparation in frozen-thawed embryo transfer cycles.Journal of the Turkish German Gynecological Association · 2016Review
- Comparison of hCG triggering versus hCG in combination with a GnRH agonist: a prospective randomized controlled trial.Facts, views & vision in ObGyn · 2014Article
- Comparison between oral and vaginal estrogen usage in inadequate endometrial patients for frozen-thawed blastocysts transfer.International journal of clinical and experimental pathology · 2014Article
- The effect of accompanying dominant follicle development/ovulation on the outcomes of frozen-thawed blastocyst transfer in HRT cycle.International journal of clinical and experimental pathology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrozen thawed embryo transfer (FET) is a cost-effective adjunct to IVF or IVF-ICSI treatment. In order to optimize treatment outcome, FET should be carried out during a period of optimal endometrial receptivity. To optimize implantation several methods for endometrium preparation have been proposed. In natural cycle FET (NC-FET), the endometrium develops under endogenous hormonal stimulation. The development of the dominant follicle and endometrium is monitored by ultrasound and FET is timed after triggering ovulation induction or determination of the spontaneous LH surge. In an artificial cycle FET (AC-FET) estrogens and progesterone are administered to prepare the endometrium for implantation. While the currently available data show no significant difference in pregnancy rates between these methods, well designed randomized controlled trials are lacking. Moreover there is little literature on difference in cancellation rates, cost-efficiency and adverse events. METHODS AND
designIn this randomized, multi-centre, non-inferiority trial we aim to test the hypothesis that there is no significant difference in live birth rates between patients undergoing NC-FET versus AC-FET. The primary outcome will be live birth rate per embryo transfer procedure. Secondary outcomes will be ongoing and clinical pregnancy rate, cancellation rate, (serious) adverse events and cost-efficiency. Based on a live birth rate of 20% and a minimal clinical important difference of 7.5% (one-sided alpha 2.5%, beta 20%) a total of 1150 patients will be needed. Analyzes will be performed using both per protocol as well as intention to treat analyses. DISCUSSION: This prospective, randomized, non-inferiority trial aims to address the hypothesis that there is no significant difference in live birth rates between patients undergoing NC-FET versus patients undergoing AC-FET. Moreover it addresses cost-efficiency as well as the perceived burden of both treatments. TRIAL REGISTER: Netherlands trial register (NTR): 1586.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.