ArticleParasites & vectors2012
Prevalence of Toxoplasma gondii antibodies, circulating antigens and DNA in stray cats in Shanghai, China.
Article in Parasites & vectors, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China.Parasites & vectors · 2017Pooled it
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- Toxoplasma gondii infection affects the complete blood count and disturbs the markers of oxidative stress from the vital organs of wild rodents.Scientific reports · 2024Article
- RPA-CRISPR/Cas12a-LFA combined with a digital visualization instrument to detectMicrobiology spectrum · 2024Article
- Prevalence ofPathogens (Basel, Switzerland) · 2022Article
- Detection of toxoplasmosis in pets and stray cats through molecular and serological techniques in Khyber Pakhtunkhwa, Pakistan.BMC veterinary research · 2021Article
- A novel loop-mediated isothermal amplification-lateral-flow-dipstick (LAMP-LFD) device for rapid detection of Toxoplasma gondii in the blood of stray cats and dogs.Parasite (Paris, France) · 2021Article
- Study on Circulating Antigens in Serum of Mice With Experimental Acute Toxoplasmosis.Frontiers in microbiology · 2020Article
- Article
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- Twenty-six circulating antigens and two novel diagnostic candidate molecules identified in the serum of canines with experimental acute toxoplasmosis.Parasites & vectors · 2016Article
- A novel dynamic flow immunochromatographic test (DFICT) using gold nanoparticles for the serological detection of Toxoplasma gondii infection in dogs and cats.Biosensors & bioelectronics · 2015Article
- Seroprevalence of Toxoplasma gondii antibodies of stray cats in Garmsar, Iran.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Seroprevalence and genotype of Toxoplasma gondii in pigs, dogs and cats from Guizhou province, Southwest China.Parasites & vectors · 2015Article
- Expression and Purification of Recombinant ROP1 of Toxoplasma gondii in Bacteria.Avicenna journal of medical biotechnology · 2013Article
- Seroprevalence and risk factors of toxoplasmosis in cattle from extensive and semi-intensive rearing systems at Zona da Mata, Minas Gerais state, Southern Brazil.Parasites & vectors · 2013Article
- Molecular and Serological Detection ofIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToxoplasma gondii is prevalent in most areas of the world and may cause abortions or neonatal complications in humans. As the only definitive host, cats play an important role in the epidemiology of the disease. Infection rates in cats, especially stray or free-living cats, are considered to be the best sentinels of the level of T. gondii in the environment. The T. gondii infection can be diagnosed in different ways with different methods depending on the target. However, little information on T. gondii infection in cats was available in Shanghai, China. Moreover reports on prevalence of circulating antigens, antibodies and DNA of T. gondii in the same study are rare.
methodsIn the present study, the presence of antibodies (Ab), circulating antigens (CA), and/or DNA of Toxoplasma gondii in samples from 145 stray or unwanted cats from 6 animal shelters in Shanghai (China) was determined in order to estimate the prevalence of T. gondii infection, by Ab-ELISA, CA-ELISA, and nested-PCR, respectively.
resultsThe positive rates for the antibodies, circulating antigen and DNA of T. gondii were 11.7% (17 of 145), 5.5% (8 of 145) and 5.71% (2 of 35), respectively. No cat tested was positive by both the Ab-ELISA and the CA-ELISA, but the results of the PCR were consistent with the CA-ELISA assay. Therefore, the overall estimated prevalence of toxoplasmosis was 17.2% (25 of 145). According to our results, the positive rates of specific antibodies and circulating antigen of T. gondii were significantly different between adult cats (>1 year old) and juvenile cats (≤1 year old); the former was 13.5% versus 3.9% by Ab-ELISA, while the latter was 1.7% versus 23.1% by CA-ELISA. From the results obtained with all three detection methods used in this study, the rate of infection was not significantly different between male and female cats (P ≥0.05); and the overall rate was 17.9% for males versus 16.4% for females.
conclusionsThe results suggest that detection of circulating antigens (CA) is necessary in surveys of T. gondii infection, especially for juvenile cats. Our investigation revealed that the prevalence of T. gondii infection in stray cats in Shanghai is high. Control programs are needed for stray cat populations in order to reduce the risk of zoonotic transmission of toxoplasmosis to other domestic animals and humans, especially females.
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