Evidence map›Paper›PMID 22950512›Full record

Trial reportTropical medicine & international health : TM & IH2012

Plasmodium falciparum, anaemia and cognitive and educational performance among school children in an area of moderate malaria transmission: baseline results of a cluster randomized trial on the coast of Kenya.

Katherine E Halliday, Peris Karanja, Elizabeth L Turner, George Okello, Kiambo Njagi, Margaret M Dubeck, Elizabeth Allen, Matthew C H Jukes, Simon J Brooker

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Tropical medicine & international health : TM & IH, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00878007 (Impact of Malaria Prevention on Health and Education in Kenyan Schoolchildren), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00878007 nacompletednot on this map

Impact of Malaria Prevention on Health and Education in Kenyan Schoolchildren

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2010 to 2012Enrolled5,177ConditionsAnaemia, MalariaArmsIntermittent screening and treatment for malaria, Teacher training on literacy instruction, IST plus literacy instruction programme
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  19. The High Burden of Malaria in Primary School Children in Southern Malawi.The American journal of tropical medicine and hygiene · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Katherine E HallidayFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK. katherine.halliday@lshtm.ac.uk
Peris Karanja
Elizabeth L Turner
George Okello
Kiambo Njagi
Margaret M Dubeck
Elizabeth Allen
Matthew C H Jukes
Simon J Brooker
London School of Hygiene & Tropical Medicine · GBKenya Medical Research Institute · KECollege of Charleston · USHarvard University · USMinistry of Health · KEUniversity of London · GB

Funding

Wellcome Trust 081673Wellcome Trust 092654Wellcome Trust 092765Wellcome Trust 098045
6 · The paper itself

Abstract

objectivesStudies have typically investigated health and educational consequences of malaria among school-aged children in areas of high malaria transmission, but few have investigated these issues in moderate transmission settings. This study investigates the patterns of and risks for Plasmodium falciparum and anaemia and their association with cognitive and education outcomes on the Kenyan coast, an area of moderate malaria transmission.

methodsAs part of a cluster randomised trial, a baseline cross-sectional survey assessed the prevalence of and risk factors for P. falciparum infection and anaemia and the associations between health status and measures of cognition and educational achievement. Results are presented for 2400 randomly selected children who were enrolled in the 51 intervention schools.

resultsThe overall prevalence of P. falciparum infection and anaemia was 13.0% and 45.5%, respectively. There was marked heterogeneity in the prevalence of P. falciparum infection by school. In multivariable analysis, being male, younger age, not sleeping under a mosquito net and household crowding were adjusted risk factors for P. falciparum infection, whilst P. falciparum infection, being male and indicators of poor nutritional intake were risk factors for anaemia. No association was observed between either P. falciparum or anaemia and performance on tests of sustained attention, cognition, literacy or numeracy.

conclusionThe results indicate that in this moderate malaria transmission setting, P. falciparum is strongly associated with anaemia, but there is no clear association between health status and education. Intervention studies are underway to investigate whether removing the burden of chronic asymptomatic P. falciparum and related anaemia can improve education outcomes.

Indexed as

Educational StatusAdolescentAge DistributionAnemiaAttentionCausalityChildChild, PreschoolCluster AnalysisCognition DisordersComorbidityCross-Sectional StudiesFamily CharacteristicsFemaleHealth StatusHumans

Identifiers

PMID22950512
PMCPMC3506732
OpenAlexW1832424805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.