ArticleAllergy, asthma & immunology research2012
Evaluation of atorvastatin for the treatment of patients with asthma: a double-blind randomized clinical trial.
Article in Allergy, asthma & immunology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Effects of atorvastatin on inflammatory markers, lipid profile, liver enzymes, and pulmonary function in patients with lung diseases: a systematic review and meta-analysis of randomized controlled trials.European journal of medical research · 2026Pooled it
- Effect of atorvastatin on testosterone levels.The Cochrane database of systematic reviews · 2021Pooled it
- Statins for asthma.The Cochrane database of systematic reviews · 2020Pooled it
- Effect of atorvastatin on serum periostin and blood eosinophils in asthma - a placebo-controlled randomized clinical trial.The Journal of international medical research · 2021Trial
- Sterols and immune mechanisms in asthma.The Journal of allergy and clinical immunology · 2023Review
- Sterols in asthma.Trends in immunology · 2022Review
- The potential of Atorvastatin for chronic lung diseases therapy.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Review
- Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies.Journal of cardiovascular and thoracic research · 2020Article
- Innovations in asthma therapy: is there a role for inhaled statins?Expert review of respiratory medicine · 2018Review
- Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma.British journal of pharmacology · 2018Article
- Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism.Current allergy and asthma reports · 2015Review
- Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins.Physiological reports · 2015Article
- Asthma and metabolic syndrome: Current knowledge and future perspectives.World journal of clinical cases · 2015Review
- Statins in Asthma: Potential Beneficial Effects and Limitations.Pulmonary medicine · 2015Review
- Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?Experimental & molecular medicine · 2014Article
- Statins and asthma: where we stand, and the next critical steps in research.Current medical research and opinion · 2014Article
- Is serum cholesterol a risk factor for asthma?Lung India : official organ of Indian Chest Society · 2013Article
- Article
- Newer treatments in the management of pediatric asthma.Paediatric drugs · 2013Review
- Statins as potential therapeutic drug for asthma?Respiratory research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStatins are known as cholesterol-lowering agents, but have been suggested for the treatment of asthma because of their anti-inflammatory effects. In this study, the potential therapeutic effects of atorvastatin were investigated in asthmatic patients.
methodsA total of 62 patients with persistent mild to moderate asthma who presented at asthma clinics of Arak University of Medical Sciences were recruited in a double-blind randomized clinical trial. The asthma clinical control score was assessed based on the standardized Asthma Control Test. Lung volume, i.e., percentage of forced expiratory volume in one second (FEV1%) and percentage of forced vital capacity (FVC%), and peripheral blood eosinophils were also measured. The intervention group was treated with atorvastatin 40 mg per day for 8 weeks, while the control group received a placebo. Asthma controller treatments were not changed. At the beginning and end of the study, serum cholesterol and triglyceride levels were measured to evaluate adherence of the patients to the treatment.
resultsThe asthma control score did not significantly differ between the intervention and control groups (P=0.06). Difference in FEV1%, FVC%, and blood eosinophil count between the intervention and control groups were not statistically significant (P>0.05). The differences in post-treatment cholesterol and low-density lipoprotein cholesterol levels were significant (P<0.05).
conclusionsOur study shows that atorvastatin is not effective in the treatment of persistent mild to moderate asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.