ArticleAllergy, asthma & immunology research2012
Immunologic evaluation of drug allergy.
Article in Allergy, asthma & immunology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Physicians' Attitudes and Practices Regarding Drug Allergy Management: A Cross-Sectional Study.Cureus · 2025Article
- Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.Antioxidants (Basel, Switzerland) · 2021Review
- Novel method to analyze cell kinetics for the rapid diagnosis and determination of the causative agent in allergy.PloS one · 2021Article
- An unusual dual hypersensitivity reaction to moxifloxacin in a patient.Asia Pacific allergy · 2018Article
- An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.Journal of immunology research · 2018Review
- The involvement of osmolarity in the safety of contrast media.Clinical and molecular allergy : CMA · 2018Article
- Recent advances in the understanding of severe cutaneous adverse reactions.The British journal of dermatology · 2017Review
- An Ofloxacin-Induced Anaphylaxis through an IgG4-Mediated but Not IgE-Mediated Basophil Activation Mechanism.Korean journal of critical care medicine · 2017Article
- Usefulness of In Vivo and In Vitro Diagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin.Allergy, asthma & immunology research · 2017Article
- Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity.Current opinion in infectious diseases · 2016Review
- Diagnosis and management of immediate hypersensitivity reactions to cephalosporins.Allergy, asthma & immunology research · 2014Review
- Immunologic evaluation of immediate hypersensitivity to cefaclor.Yonsei medical journal · 2014Article
- Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays.Asia Pacific allergy · 2014Article
- Molecular genetic mechanisms of chronic urticaria.Allergy, asthma & immunology research · 2014Review
- A Case of Codeine Induced Anaphylaxis via Oral Route.Allergy, asthma & immunology research · 2014Article
- Testing for drug hypersensitivity syndromes.The Clinical biochemist. Reviews · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypersensitivity drug reactions (HDR) consist of an individual abnormal response with the involvement of the immunological system. In addition to specific immunological mechanisms where specific antibodies or sensitised T cells participate, release of inflammatory mediators by non-specific immunological recognition may also occur. Within this category are one of the most common groups of drugs, the non-steroidal anti-inflammatory drugs. In addition to chemical drugs new emerging ones with an increasing protagonism are biological agents like humanised antibodies and others. For IgE dependent reactions both in vivo and in vitro tests can be used for the immunological evaluation. Sensitivity of these is not optimal and very often a drug provocation test must be considered for knowing the mechanism involved and/or establishing the diagnosis. For non-immediate reactions also both in vivo and in vitro tests can be used. Sensitivity for in vivo tests is generally low and in vitro tests may be needed for the immunological evaluation. Immunohistochemical studies of the affected tissue enable a more precise classification of non-immediate reactions. The monitorization of the acute response of the reactions has given clues for understanding these reactions and has promising results for the future of the immunological evaluation of HDR.
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Registered trials
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