ArticleInternational journal of molecular sciences2012
Gender related differences in kidney injury induced by mercury.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Re-thinking the link between exposure to mercury and blood pressure.Archives of toxicology · 2025Pooled it
- Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease.BMC nephrology · 2025Review
- Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans?Clinical pharmacology and therapeutics · 2024Article
- The Protective Activity ofInternational journal of nephrology · 2024Article
- Metalloproteomic Investigation of Hg-Binding Proteins in Renal Tissue of Rats Exposed to Mercury Chloride.International journal of molecular sciences · 2023Article
- Toxic Nephropathy Secondary to Chronic Mercury Poisoning: Clinical Characteristics and Outcomes.Kidney international reports · 2022Article
- Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment.Metabolic brain disease · 2022Article
- Association of Blood Mercury Levels with the Risks of Overweight and High Waist-to-Height Ratio in Children and Adolescents: Data from the Korean National Health and Nutrition Examination Survey.Children (Basel, Switzerland) · 2021Article
- Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review.Toxicology reports · 2018Review
- Xenobiotic transporters and kidney injury.Advanced drug delivery reviews · 2017Review
- Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.Environmental health perspectives · 2016Article
- Age and sex differences in kidney microRNA expression during the life span of F344 rats.Biology of sex differences · 2015Article
- Expression of drug transporters in human kidney: impact of sex, age, and ethnicity.Biology of sex differences · 2015Article
- Sex-dependent regulation of cytochrome P450 family members Cyp1a1, Cyp2e1, and Cyp7b1 by methylation of DNA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Sex differences in kidney gene expression during the life cycle of F344 rats.Biology of sex differences · 2013Article
- Developmental study of mercury effects on the fruit fly (Drosophila melanogaster).Interdisciplinary toxicology · 2013Article
- Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine if there are sex-related differences in the acute kidney injury induced by HgCl(2) since female rats express lower levels of renal Oat1 and Oat3 (transporters involved in renal uptake of mercury) as compared with males. Control males and females and Hg-treated male and female Wistar rats were employed. Animals were treated with HgCl(2) (4 mg/kg body weight (b.w.), intraperitoneal (i.p.)) 18 h before the experiments. HgCl(2) induced renal impairment both in male and female rats. However, female rats showed a lower renal impairment than male rats. The observed increase in kidney weight/body weight ratio seen in male and female rats following HgCl(2) treatment was less in the female rats. Urine volume and creatinine clearance decreased and Oat5 urinary excretion increased in both males and females, but to a lesser degree in the latter. Urinary alkaline phosphatase (AP) activity and histological parameters were modified in male but not in female rats after HgCl(2) administration. These results indicate that the lower Oat1 and Oat3 expression in the kidney of females restricts Hg uptake into renal cells protecting them from this metal toxicity. These gender differences in renal injury induced by mercury are striking and also indicate that Oat1 and Oat3 are among the main transporters responsible for HgCl(2)-induced renal injury.
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