ArticleInternational journal of molecular sciences2012
Quantitative expression of C-type lectin receptors in humans and mice.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
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- Removal of Mannose-Ending Glycan at AsnFrontiers in immunology · 2020Article
- Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).The Journal of biological chemistry · 2018Article
- Tumor Necrosis Factor-α in Heart Failure: an Updated Review.Current cardiology reports · 2018Review
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- IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis.Physiological reports · 2018Article
- The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure.Mediators of inflammation · 2018Review
- Interactions of Surface Exopolysaccharides FromFrontiers in microbiology · 2018Review
- Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury.Bioscience reports · 2017Article
- Tumor necrosis factor superfamily ligand mRNA expression profiles differ between humans and mice during homeostasis and between various murine kidney injuries.Journal of biomedical science · 2017Article
- Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore determined the mRNA expression levels of Dectin-1, MR1, MR2, DC-SIGN, Syk, Card-9, Bcl-10, Malt-1, Src, Dec-205, Galectin-1, Tim-3, Trem-1, and DAP-12 in 11 solid organs of human and mice. Mouse organs revealed lower mRNA levels of most molecules compared to spleen. However, Dec-205 and Galectin-1 in thymus, Src in brain, MR2, Card-9, Bcl-10, Src, and Dec-205 in small intestine, MR2, Bcl-10, Src, Galectin-1 in kidney, and Src and Galectin-1 in muscle were at least 2-fold higher expressed compared to spleen. Human lung, liver and heart expressed higher mRNA levels of most genes compared to spleen. Dectin-1, MR1, Syk and Trem-1 mRNA were strongly up-regulated upon ischemia-reperfusion injury in murine kidney. Tim3, DAP-12, Card-9, DC-SIGN and MR2 were further up-regulated during renal fibrosis. Murine kidney showed higher DAP-12, Syk, Card-9 and Dectin-1 mRNA expression during the progression of lupus nephritis. Thus, the organ-, and species-specific expression of C-type lectin receptors is different between mice and humans which must be considered in the interpretation of related studies.
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