ReviewInternational journal of molecular sciences2012
Molecular mechanisms of aging and immune system regulation in Drosophila.
Review in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response.PLoS genetics · 2023Article
- Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior.iScience · 2022Article
- Relationship between oxidative stress and lifespan in Daphnia pulex.Scientific reports · 2022Article
- The Impact of Age on Response to Infection inMicroorganisms · 2021Review
- Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis.Frontiers in physiology · 2020Review
- Longer life span is associated with elevated immune activity in a seasonally polyphenic butterfly.Journal of evolutionary biology · 2019Article
- Evolution of longevity improves immunity inEvolution letters · 2018Article
- Unraveling the Molecular Mechanism of Immunosenescence inInternational journal of molecular sciences · 2018Review
- Longevity extension in Drosophila through gut-brain communication.Scientific reports · 2018Article
- The interplay between immunity and aging inF1000Research · 2018Review
- Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.Experimental gerontology · 2017Article
- Review
- The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila.Immunity & ageing : I & A · 2016Article
- Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster.Genetics research international · 2015Article
- Population dynamics and growth rates of endosymbionts during Diaphorina citri (Hemiptera, Liviidae) ontogeny.Microbial ecology · 2014Article
- Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila.Aging · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.