ArticleInternational journal of molecular sciences2012
Detection of differential levels of proteins in the urine of patients with endometrial cancer: analysis using two-dimensional gel electrophoresis and o-glycan binding lectin.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Advances in urinary biomarkers for endometrial cancer detection.British journal of cancer · 2026Review
- Article
- Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women.British journal of cancer · 2023Article
- The Latest Developments in Using Proteomic Biomarkers from Urine and Serum for Non-Invasive Disease Diagnosis and Prognosis.Biomarker insights · 2023Review
- Protein biomarkers in cervicovaginal lavages for detection of endometrial cancer.Biomarker research · 2022Article
- Glycosylation and its research progress in endometrial cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Review
- New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers.Cancers · 2021Review
- Novel diagnostic options for endometriosis - Based on the glycome and microbiome.Journal of advanced research · 2021Review
- Article
- Urinary Biomarkers and Their Potential for the Non-Invasive Detection of Endometrial Cancer.Frontiers in oncology · 2020Review
- Review
- Article
- Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract.Frontiers in pharmacology · 2015Article
- Identification of protein markers in patients infected with Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax.International journal of molecular sciences · 2014Article
- Boronic Acid-based approach for separation and immobilization of glycoproteins and its application in sensing.International journal of molecular sciences · 2013Review
- Identification of O-glycosylated proteins that are aberrantly excreted in the urine of patients with early stage ovarian cancer.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancers can cause some proteins to be aberrantly excreted or released in the urine, which can be used as biomarkers. To screen for potential biomarkers for endometrial cancer (ECa), the urinary proteins from patients who were newly diagnosed with early stage ECa and untreated controls were separated using two-dimensional gel electrophoresis (2-DE) and followed by image analysis. The altered levels of zinc alpha-2 glycoprotein, alpha 1-acid glycoprotein, and CD59 were detected in the patients compared to the controls. In addition, the urine of the ECa patients was also found to contain relatively lower levels of a fragment of nebulin when the 2-DE separated urinary proteins were probed using champedak galactose binding (CGB) lectin. The different levels of the nebulin fragment were further validated by subjecting the urinary protein samples to CGB lectin affinity chromatography and analysis of the bound fractions by LC-MS/MS. Our data is suggestive of the potential use of the differentially expressed urinary proteins as biomarkers for ECa although this requires further extensive validation on clinically representative populations.
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