ArticleProceedings of the National Academy of Sciences of the United States of America2012
Geometry sensing by self-organized protein patterns.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Mimicking Cellular Membranes With Micropatterned Lipid Bilayers.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- 3D pattern formation of a protein-membrane suspension.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Quantum transport in protein chains.Scientific reports · 2025Article
- Self-organized spatial targeting of contractile actomyosin rings for synthetic cell division.Nature communications · 2024Article
- Insights into the assembly and regulation of the bacterial divisome.Nature reviews. Microbiology · 2024Review
- Forceful patterning: theoretical principles of mechanochemical pattern formation.EMBO reports · 2023Review
- The mechanism of MinD stability modulation by MinE in Min protein dynamics.PLoS computational biology · 2023Article
- Sensing the shape of a cell with reaction diffusion and energy minimization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.Communications biology · 2022Article
- Mode selection mechanism in traveling and standing waves revealed by Min wave reconstituted in artificial cells.Science advances · 2022Article
- Stochasticity and positive feedback enable enzyme kinetics at the membrane to sense reaction size.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- DivIVA Regulates Its Expression and the Orientation of New Septum Growth in Deinococcus radiodurans.Journal of bacteriology · 2021Article
- Engineering spatiotemporal organization and dynamics in synthetic cells.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Article
- The E. coli MinCDE system in the regulation of protein patterns and gradients.Cellular and molecular life sciences : CMLS · 2019Review
- Cell morphology and nucleoid dynamics in dividing Deinococcus radiodurans.Nature communications · 2019Article
- Article
- Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Active Transport of Membrane Components by Self-Organization of the Min Proteins.Biophysical journal · 2019Article
- Geometric Effect for Biological Reactors and Biological Fluids.Bioengineering (Basel, Switzerland) · 2018Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the living cell, proteins are able to organize space much larger than their dimensions. In return, changes of intracellular space can influence biochemical reactions, allowing cells to sense their size and shape. Despite the possibility to reconstitute protein self-organization with only a few purified components, we still lack knowledge of how geometrical boundaries affect spatiotemporal protein patterns. Following a minimal systems approach, we used purified proteins and photolithographically patterned membranes to study the influence of spatial confinement on the self-organization of the Min system, a spatial regulator of bacterial cytokinesis, in vitro. We found that the emerging protein pattern responds even to the lateral, two-dimensional geometry of the membrane such that, as in the three-dimensional cell, Min protein waves travel along the longest axis of the membrane patch. This shows that for spatial sensing the Min system does not need to be enclosed in a three-dimensional compartment. Using a computational model we quantitatively analyzed our experimental findings and identified persistent binding of MinE to the membrane as requirement for the Min system to sense geometry. Our results give insight into the interplay between geometrical confinement and biochemical patterns emerging from a nonlinear reaction-diffusion system.
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