ArticleProceedings of the National Academy of Sciences of the United States of America2012
Reproductive clonality of pathogens: a perspective on pathogenic viruses, bacteria, fungi, and parasitic protozoa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Host switching via rare sex: Oncorhynchus mykiss as a vector in fusion of three Gyrodactylus salaris genomes into a sexual-clonal population on a landlocked Salmo salar (Monogenea, Platyhelminthes).Folia parasitologica · 2026Article
- Epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure.PLoS computational biology · 2026Article
- Genetic-Geographic-Chemical Framework ofJournal of fungi (Basel, Switzerland) · 2026Article
- Large- and small-scale population structure ofApplied and environmental microbiology · 2025Article
- The Relevance of the Predominant Clonal Evolution (PCE) Model for the Molecular Epidemiology and Subspecific Taxonomy ofPathogens (Basel, Switzerland) · 2025Review
- An Overview ofPathogens (Basel, Switzerland) · 2025Review
- Seasonality and interannual stability in the population genetic structure of Batrachospermum gelatinosum (Rhodophyta).Journal of phycology · 2025Article
- Review
- Epidemiology of Chagas Disease in the United States of America: A Short Review and Some Comments.Pathogens (Basel, Switzerland) · 2025Review
- BALB/c mice infection with hybridFrontiers in cellular and infection microbiology · 2025Article
- Diversity and dissemination of viruses in pathogenic protozoa.Nature communications · 2023Article
- Population genomics reveals meiotic recombination inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Attack of the clones: Population genetics reveals clonality of Colletotrichum lupini, the causal agent of lupin anthracnose.Molecular plant pathology · 2023Article
- Forest health in the Anthropocene: the emergence of a novel tree disease is associated with poplar cultivation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- High-Throughput Microsatellite Markers Development for Genetic Characterization of EmergingJournal of fungi (Basel, Switzerland) · 2023Article
- Subspecific Nomenclature ofPathogens (Basel, Switzerland) · 2023Article
- A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics.Infectious diseases of poverty · 2022Article
- Article
- Microevolution ofeLife · 2022Article
33 more citing papers are in PubMed but not listed here.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We propose that clonal evolution in micropathogens be defined as restrained recombination on an evolutionary scale, with genetic exchange scarce enough to not break the prevalent pattern of clonal population structure, a definition already widely used for all kinds of pathogens, although not clearly formulated by many scientists and rejected by others. The two main manifestations of clonal evolution are strong linkage disequilibrium (LD) and widespread genetic clustering ("near-clading"). We hypothesize that this pattern is not mainly due to natural selection, but originates chiefly from in-built genetic properties of pathogens, which could be ancestral and could function as alternative allelic systems to recombination genes ("clonality/sexuality machinery") to escape recombinational load. The clonal framework of species of pathogens should be ascertained before any analysis of biomedical phenotypes (phylogenetic character mapping). In our opinion, this model provides a conceptual framework for the population genetics of any micropathogen.
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