ArticleProceedings of the National Academy of Sciences of the United States of America2012
Biased inheritance of the protein PatN frees vegetative cells to initiate patterned heterocyst differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Hacking heterocysts: advances in the genetic regulation of heterocyst differentiation.Archives of microbiology · 2025Review
- A new family of bacterial actin-like proteins regulates cell morphology in a filamentous cyanobacterium.mSphere · 2025Article
- Inheritance of extraordinary metabolic activity from parental bacteria individuals.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- EbsA is essential for both motility and biofilm formation in the filamentous cyanobacteriumMicrobiology (Reading, England) · 2024Article
- The role of FraI in cell-cell communication and differentiation in the hormogonia-forming cyanobacteriummSphere · 2024Article
- Accelerating the discovery of alkyl halide-derived natural products using halide depletion.Nature chemistry · 2024Article
- PatU3 plays a central role in coordinating cell division and differentiation in pattern formation of filamentous cyanobacterium Nostoc sp. PCC 7120.Science China. Life sciences · 2023Article
- A proteolytic pathway coordinates cell division and heterocyst differentiation in the cyanobacteriumProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Terminal heterocyst differentiation in the Anabaena patA mutant as a result of post-transcriptional modifications and molecular leakage.PLoS computational biology · 2022Article
- Interaction network among factors involved in heterocyst-patterning in cyanobacteria.Molecular genetics and genomics : MGG · 2022Article
- Article
- Mathematical models of nitrogen-fixing cell patterns in filamentous cyanobacteria.Frontiers in cell and developmental biology · 2022Review
- The cyanobacterial taxis protein HmpF regulates type IV pilus activity in response to light.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Expression from DIF1-motif promoters of hetR and patS is dependent on HetZ and modulated by PatU3 during heterocyst differentiation.PloS one · 2020Article
- Article
- Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism.PLoS biology · 2018Article
- Spatially Correlated Gene Expression in Bacterial Groups: The Role of Lineage History, Spatial Gradients, and Cell-Cell Interactions.Cell systems · 2018Article
- Spatial separation of photosynthesis and ethanol production by cell type-specific metabolic engineering of filamentous cyanobacteria.Applied microbiology and biotechnology · 2018Article
- Role of PatS and cell type on the heterocyst spacing pattern in a filamentous branching cyanobacterium.FEMS microbiology letters · 2017Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Heterocysts, cells specialized for nitrogen fixation in certain filamentous cyanobacteria, appear singly in a nonrandom spacing pattern along the chain of vegetative cells. A two-stage, biased initiation and competitive resolution model has been proposed to explain the establishment of this spacing pattern. There is substantial evidence that competitive resolution of a subset of cells initiating differentiation occurs by interactions between a self-enhancing activator protein, HetR, and a diffusible pentapeptide inhibitor PatS-5 (RGSGR). Results presented here show that the absence of a unique membrane protein, PatN, in Nostoc punctiforme strain ATCC 29133 leads to a threefold increase in heterocyst frequency and a fourfold decrease in the vegetative cell interval between heterocysts. A PatN-GFP translational fusion shows a pattern of biased inheritance in daughter vegetative cells of ammonium-grown cultures. Inactivation of another heterocyst patterning gene, patA, is epistatic to inactivation of patN, and transcription of patA increases in a patN-deletion strain, implying that patN may function by modulating levels of patA. The presence of PatN is hypothesized to decrease the competency of a vegetative cell to initiate heterocyst differentiation, and the cellular concentration of PatN is dependent on cell division that results in cells transiently depleted of PatN. We suggest that biased inheritance of cell-fate determinants is a phylogenetic domain-spanning paradigm in the development of biological patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.