ArticleMolecular and cellular biology2012
Geminin regulates the transcriptional and epigenetic status of neuronal fate-promoting genes during mammalian neurogenesis.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.Chromosoma · 2018Review
- DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells.Human cell · 2018Article
- Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling.BioMed research international · 2018Article
- Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors.Genes & cancer · 2017Article
- Foxd4 is essential for establishing neural cell fate and for neuronal differentiation.Genesis (New York, N.Y. : 2000) · 2017Article
- Dual roles of Akirin2 protein duringThe Journal of biological chemistry · 2017Article
- Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1.Scientific reports · 2016Article
- GEMC1 is a critical regulator of multiciliated cell differentiation.The EMBO journal · 2016Article
- Mcidas and GemC1/Lynkeas specify embryonic radial glial cells.Neurogenesis (Austin, Tex.) · 2016Article
- Cell cycle regulation of proliferation versus differentiation in the central nervous system.Cell and tissue research · 2015Review
- Neural transcription factors: from embryos to neural stem cells.Molecules and cells · 2014Review
- Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.Developmental biology · 2014Article
- Nervous decision-making: to divide or differentiate.Trends in genetics : TIG · 2014Review
- Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Transcription of the Geminin gene is regulated by a negative-feedback loop.Molecular biology of the cell · 2014Article
- Geminin is required for the maintenance of pluripotency.PloS one · 2013Article
- On becoming neural: what the embryo can tell us about differentiating neural stem cells.American journal of stem cells · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Regulating the transition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of nervous system development. Here, we investigated the role of the nucleoprotein geminin in regulating neurogenesis at a mechanistic level during both Xenopus primary neurogenesis and mammalian neuronal differentiation in vitro. The latter work utilized neural cells derived from embryonic stem and embryonal carcinoma cells in vitro and neural stem cells from mouse forebrain. In all of these contexts, geminin antagonized the ability of neural basic helix-loop-helix (bHLH) transcription factors to activate transcriptional programs promoting neurogenesis. Furthermore, geminin promoted a bivalent chromatin state, characterized by the presence of both activating and repressive histone modifications, at genes encoding transcription factors that promote neurogenesis. This epigenetic state restrains the expression of genes that regulate commitment of undifferentiated stem and neuronal precursor cells to neuronal lineages. However, maintaining geminin at high levels was not sufficient to prevent terminal neuronal differentiation. Therefore, these data support a model whereby geminin promotes the neuronal precursor cell state by modulating both the epigenetic status and expression of genes encoding neurogenesis-promoting factors. Additional developmental signals acting in these cells can then control their transition toward terminal neuronal or glial differentiation during mammalian neurogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.