Evidence map›Paper›PMID 22949090›Full record

ReviewPflugers Archiv : European journal of physiology2013

AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function.

Shetal H Padia, Robert M Carey

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 135 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
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  7. Review
  8. Review
  9. Review
  10. Review
  11. The ATMolecules (Basel, Switzerland) · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Whey-Derived Peptides at the Heart of the COVID-19 Pandemic.International journal of molecular sciences · 2021
    Article
  17. Article
  18. Endocrine · 2021
    Article
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shetal H PadiaDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, P.O. Box 801414, Charlottesville, VA 22908, USA.
Robert M Carey
University of Virginia Health System · US

Funding

Renal AT2 Receptors in HypertensionR01HL095796 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAREY, ROBERT MUNSON · 2010 to 2013
$1.7M
NHLBI NIH HHS R01 HL095796
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is a coordinated hormonal cascade intimately involved in cardiovascular and renal control and blood pressure regulation. Angiotensin II (Ang II), the major RAS effector peptide, binds two distinct receptors, the angiotensin type-1 receptor (AT(1)R) and the angiotensin type-2 (AT(2)R) receptor. The vast majority of the physiological actions of Ang II, almost all of them detrimental, are mediated by AT(1)Rs. In contrast, AT(2)Rs negatively modulate the actions of AT(1)Rs under the majority of circumstances and generally possess beneficial effects. AT(2)Rs induce vasodilation in both resistance and capacitance vessels, mediating natriuresis directly and via interactions with dopamine D1 receptors in the renal proximal tubule. AT(2)Rs inhibit renin biosynthesis and secretion and protect the kidneys from inflammation and ischemic injury. Our understanding of the exact role of AT(2)Rs in physiology and pathophysiology continues to expand; the purpose of this review is to provide an up-to-date summary of the functional role of AT(2)Rs at the organ, tissue, cellular, and subcellular levels with emphasis on the vascular and renal actions that bear on blood pressure regulation and hypertension.

Indexed as

NatriuresisVasodilationAngiotensin IIAnimalsHumansReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2ReninRenin-Angiotensin SystemSignal TransductionAngiotensin IIReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Renin

Identifiers

PMID22949090
PMCPMC3548020
OpenAlexW2122766152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.