ArticleStem cells (Dayton, Ohio)2012
Immunomodulation by transplanted human embryonic stem cell-derived oligodendroglial progenitors in experimental autoimmune encephalomyelitis.
Article in Stem cells (Dayton, Ohio), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Cell replacement therapy with stem cells in multiple sclerosis, a systematic review.Human cell · 2024Pooled it
- Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review.International journal of nanomedicine · 2014Pooled it
- Demyelination and Remyelination: General Principles.Advances in neurobiology · 2025Review
- Glial-restricted progenitor cells: a cure for diseased brain?Biological research · 2024Review
- Oligodendrocyte Progenitor Cell Transplantation Ameliorates Preterm Infant Cerebral White Matter Injury in Rats Model.Neuropsychiatric disease and treatment · 2023Article
- Transplantation of Human Glial Progenitors to Immunodeficient Neonatal Mice with Amyotrophic Lateral Sclerosis (SOD1/rag2).Antioxidants (Basel, Switzerland) · 2022Article
- Evaluation of cell transplant-mediated attenuation of diffuse injury in experimental autoimmune encephalomyelitis using onVDMP CEST MRI.Experimental neurology · 2020Article
- Continuous Immune-Modulatory Effects of Human Olig2+ Precursor Cells Attenuating a Chronic-Active Model of Multiple Sclerosis.Molecular neurobiology · 2020Article
- Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells.Frontiers in cellular neuroscience · 2019Article
- Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model.Cell death discovery · 2018Article
- Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer's Disease.BioMed research international · 2018Review
- TREM2 in Neurodegenerative Diseases.Molecular neurodegeneration · 2017Review
- The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.Cell death & disease · 2017Article
- Neural Subtype Specification from Human Pluripotent Stem Cells.Cell stem cell · 2016Review
- Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells.Journal of visualized experiments : JoVE · 2015Article
- Article
- Analysis of neurogenesis during experimental autoimmune encephalomyelitis reveals pitfalls of bioluminescence imaging.PloS one · 2015Article
- Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis.Stem cell reports · 2014Article
- The neuroprotective effect exerted by oligodendroglial progenitors on ischemically impaired hippocampal cells.Molecular neurobiology · 2014Article
- The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis.Multiple sclerosis international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Transplantation of embryonic stem cells and their neural derivatives can lead to amelioration of the disease symptoms of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Oligodendroglial progenitors (OPs), derived from human embryonic stem cells (hESC, HES-1), were labeled with superparamagnetic iron oxide and transduced with luciferase. At 7 days following induction of EAE in C57/BL6 mice, 1 × 10(6) cells were transplanted in the ventricles of C57/BL6 mice and noninvasively monitored by magnetic resonance and bioluminescence imaging. Cells were found to remain within the cerebroventricular system and did not survive for more than 10 days. However, EAE mice that received hESC-OPs showed a significant improvement in neurological disability scores (0.9 ± 0.2; n = 12) compared to that of control animals (3.3 ± 0.4; n = 12) at day 15 post-transplantation. Histopathologically, transplanted hESC-OPs generated TREM2-positive CD45 cells, increased TIMP-1 expression, confined inflammatory cells within the subarachnoid space, and gave rise to higher numbers of Foxp3-positive regulatory T cells in the spinal cord and spleen. Our results suggest that transplantation of hESC-OPs can alter the pathogenesis of EAE through immunomodulation, potentially providing new avenues for stem cell-based treatment of MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.