ArticleActa crystallographica. Section D, Biological crystallography2012
Experimental phasing using zinc anomalous scattering.
Article in Acta crystallographica. Section D, Biological crystallography, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
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- Implementation of wedged-serial protein crystallography at PROXIMA-1.Journal of synchrotron radiation · 2022Article
- Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants.Scientific reports · 2021Article
- Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila.Nature communications · 2020Article
- The hydrogen peroxide hypersensitivity of OxyR2 inThe Journal of biological chemistry · 2017Article
- Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction.Journal of bacteriology · 2016Article
- Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins.Journal of structural biology · 2016Article
- Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase.PloS one · 2016Article
- Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a D,L-carboxypeptidase controlling the helical cell shape.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Experimental phasing using zinc and sulfur anomalous signals measured at the zinc absorption peak.Journal of microbiology (Seoul, Korea) · 2013Article
- The binding of zinc ions to Emericella nidulans endo-β-1,4-galactanase is essential for crystal formation.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- In-house zinc SAD phasing at Cu Kα edge.Molecules and cells · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is a suitable metal for anomalous dispersion phasing methods in protein crystallography. Structure determination using zinc anomalous scattering has been almost exclusively limited to proteins with intrinsically bound zinc(s). Here, it is reported that multiple zinc ions can easily be charged onto the surface of proteins with no intrinsic zinc-binding site by using zinc-containing solutions. Zn derivatization of protein surfaces appears to be a largely unnoticed but promising method of protein structure determination.
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