ArticleAntimicrobial agents and chemotherapy2012
Regulation of RamA by RamR in Salmonella enterica serovar Typhimurium: isolation of a RamR superrepressor.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A specific amount of RamA must be reached to trigger increased expression of AcrAB, enhance efflux, and confer multidrug resistance.Nucleic acids research · 2026Article
- Gene Expression Analysis and Whole Genome Sequencing Reveal the Potential Mechanism of Ciprofloxacin Resistance in aVeterinary sciences · 2026Article
- Structure-Based Drug Design Targeting the Substrate-Binding Pocket of MexB.The protein journal · 2026Review
- EPS inhibitor treatment of Salmonella impacts evolution without selecting for resistance to biofilm inhibition.NPJ biofilms and microbiomes · 2025Article
- Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis.Biosensors · 2023Review
- Antimicrobial Resistance and Mechanisms of Azithromycin Resistance in Nontyphoidal Salmonella Isolates in Taiwan, 2017 to 2018.Microbiology spectrum · 2023Article
- EnvR is a potent repressor of acrAB transcription in Salmonella.The Journal of antimicrobial chemotherapy · 2022Article
- Reduced Efflux Pumps Expression ofIranian journal of medical sciences · 2020Article
- Article
- An Intertwined Network of Regulation Controls Membrane Permeability Including Drug Influx and Efflux in Enterobacteriaceae.Microorganisms · 2020Review
- TetR-family transcription factors in Gram-negative bacteria: conservation, variation and implications for efflux-mediated antimicrobial resistance.BMC genomics · 2019Article
- CsrA maximizes expression of the AcrAB multidrug resistance transporter.Nucleic acids research · 2017Article
- Computational Analysis of the Molecular Mechanism of RamR Mutations Contributing to Antimicrobial Resistance in Salmonella enterica.Scientific reports · 2017Article
- RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition.Frontiers in microbiology · 2015Review
- RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease.The Journal of antimicrobial chemotherapy · 2014Article
- Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA.The Journal of antimicrobial chemotherapy · 2013Article
- MarA, SoxS and Rob ofInternational journal of biotechnology for wellness industries · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
RamA is a transcription factor involved in regulating multidrug resistance in Salmonella enterica serovar Typhimurium SL1344. Green fluorescent protein (GFP) reporter fusions were exploited to investigate the regulation of RamA expression by RamR. We show that RamR represses the ramA promoter by binding to a palindromic sequence and describe a superrepressor RamR mutant that binds to the ramA promoter sequence more efficiently, thus exhibiting a ramA inactivated phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.