ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
Effect of the artificial sweetener, acesulfame potassium, a sweet taste receptor agonist, on glucose uptake in small intestinal cell lines.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of prenatal artificial sweeteners consumption on birth outcomes: a systematic review and meta-analysis.Public health nutrition · 2021Pooled it
- In Vitro Testing of Artificial Sweeteners with Apple and Chokeberry Fruit Juice Extracts for Intestinal Permeability and Glucose Uptake.ACS omega · 2026Article
- Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoENutrients · 2021Article
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Aspartame, acesulfame K and sucralose- influence on the metabolism ofMetabolism open · 2020Article
- Low-calorie sweeteners augment tissue-specific insulin sensitivity in a large animal model of obesity.European journal of nuclear medicine and molecular imaging · 2019Article
- Acute saccharin infusion has no effect on renal glucose handling in normal rats in vivo.Physiological reports · 2018Article
- Phloridzin inhibits high KThe Journal of veterinary medical science · 2017Article
- Plasma concentrations of sucralose in children and adults.Toxicological and environmental chemistry · 2017Article
- A High-Throughput Automated Microfluidic Platform for Calcium Imaging of Taste Sensing.Molecules (Basel, Switzerland) · 2016Article
- Duodenal luminal nutrient sensing.Current opinion in pharmacology · 2014Review
- Lack of functionally active sweet taste receptors in the jejunum in vivo in the rat.The Journal of surgical research · 2013Article
- Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
introductionSweet taste receptors may enhance glucose absorption.
aimThis study aimed to explore the cell biology of sweet taste receptors on glucose uptake. HYPOTHESIS: Artificial sweeteners increase glucose uptake via activating sweet taste receptors in the enterocyte to translocate GLUT2 to the apical membrane through the PLC βII pathway.
methodsCaco-2, RIE-1, and IEC-6 cells, starved from glucose for 1 h were pre-incubated with 10 mM acesulfame potassium (AceK). Glucose uptake was measured by incubating cells for 1 to 10 min with 0.5-50 mM glucose with or without U-73122, chelerythrine, and cytochalasin B.
resultsIn Caco-2 and RIE-1 cells, 10 mM AceK increased glucose uptake by 20-30 % at glucose >25 mM, but not in lesser glucose concentrations (<10 mM), nor at 1 min or 10 min incubations. U-73122 (PLC βII inhibitor) inhibited uptake at glucose >25 mM and for 5 min incubation; chelerythrine and cytochalasin B had similar effects. No effect occurred in IEC-6 cells. Activation of sweet taste receptors had no effect on glucose uptake in low (<25 mM) glucose concentrations but increased uptake at greater concentrations (>25 mM).
conclusionsRole of artificial sweeteners on glucose uptake appears to act in part by effects on the enterocyte itself.
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