ArticleStem cells (Dayton, Ohio)2012
Subventricular zone localized irradiation affects the generation of proliferating neural precursor cells and the migration of neuroblasts.
Article in Stem cells (Dayton, Ohio), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Negative impact of hippocampal radiotherapy dose on memory function in patients with brain metastases.Neuro-oncology practice · 2026Article
- Decreased overall survival in patients with brain metastases from non-small cell lung cancer with radiotherapy dose on the neurogenic niches.Technical innovations & patient support in radiation oncology · 2026Article
- Photoperiodism, testosterone and adult neurogenesis in canaries (Serinus canaria).Journal of neuroendocrinology · 2025Review
- Effects of PreOperative radiotherapy in a preclinical glioblastoma model: a paradigm-shift approach.Journal of neuro-oncology · 2024Article
- Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis.Frontiers in neuroendocrinology · 2023Review
- Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries.Scientific reports · 2023Article
- Therapy Resistance of Glioblastoma in Relation to the Subventricular Zone: What Is the Role of Radiotherapy?Cancers · 2023Article
- Article
- Assessment of Normal Tissue Radiosensitivity by Evaluating DNA Damage and Repair Kinetics in Human Brain Organoids.International journal of molecular sciences · 2021Article
- Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation.Cell reports. Medicine · 2021Article
- Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement.Journal of neuro-oncology · 2020Article
- Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation.Stem cells (Dayton, Ohio) · 2019Article
- Review
- Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy.Frontiers in cellular neuroscience · 2019Article
- Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia.Neuroscience · 2018Article
- Altered brain morphology after focal radiation reveals impact of off-target effects: implications for white matter development and neurogenesis.Neuro-oncology · 2018Article
- Space Invaders: Brain Tumor Exploitation of the Stem Cell Niche.The American journal of pathology · 2018Review
- Brain Radiation Necrosis: Current Management With a Focus on Non-small Cell Lung Cancer Patients.Frontiers in oncology · 2018Review
- The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation.Aging and disease · 2017Review
- Radio-Protective Effects of Melatonin on Subventricular Zone in Irradiated Rat: Decrease in Apoptosis and Upregulation of Nestin.Journal of molecular neuroscience : MN · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Radiation therapy is a part of the standard treatment for brain tumor patients, often resulting in irreversible neuropsychological deficits. These deficits may be due to permanent damage to the neural stem cell (NSC) niche, damage to local neural progenitors, or neurotoxicity. Using a computed tomography-guided localized radiation technique, we studied the effects of radiation on NSC proliferation and neuroblast migration in the mouse brain. Localized irradiation of the subventricular zone (SVZ) eliminated the proliferating neural precursor cells and migrating neuroblasts. After irradiation, type B cells in the SVZ lacked the ability to generate migrating neuroblasts. Neuroblasts from the unirradiated posterior SVZ did not follow their normal migratory path through the irradiated anterior SVZ. Our results indicate that the migrating neuroblasts were not replenished, despite the presence of type B cells in the SVZ post-irradiation. This study provides novel insights into the effects of localized SVZ radiation on neurogenesis and cell migration that may potentially lead to the development of new radiotherapy strategies to minimize damage to NSCs and neuroblast migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.