ArticleJAMA2012
Older adults with severe, treatment-resistant depression.
Article in JAMA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Animal-assisted interventions for depression in older adults: an umbrella review with meta-analysis and trial sequential analysis.Aging clinical and experimental research · 2026Pooled it
- Amphetamine Use in the Elderly: A Systematic Review of the Literature.Current neuropharmacology · 2020Pooled it
- Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.Lancet (London, England) · 2015Trial
- MDMA-Assisted Treatment for PTSD, Anxiety, and Depression: A Visualized Literature Analysis over 30 Years.Current medicinal chemistry · 2026Review
- Three-Year Prognosis of Late-Life Depression in an Outpatient Geriatric Psychiatry Clinic: Medical Comorbidities Worsen Outcomes.The Psychiatric quarterly · 2023Article
- Depression in the Elderly. Consensus Statement of the Spanish Psychogeriatric Association.Frontiers in psychiatry · 2020Article
- Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression.Frontiers in aging neuroscience · 2018Review
- What Should be Done When Elderly Patients with Major Depression Have Failed to Respond to All Treatments?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Disparities in Treatment of Older Adults with Suicide Risk in the Emergency Department.Journal of the American Geriatrics Society · 2017Article
- Depression Outcomes in Adults Attending Family Practice Were Not Improved by Screening, Stepped-Care, or Online CBT during a 12-Week Study when Compared to Controls in a Randomized Trial.Frontiers in psychiatry · 2017Article
- Clinicians' Views on Treatment-Resistant Depression: 2016 Survey Reports.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Article
- Older Adults' Perspectives on Clinical Research: A Focus Group and Survey Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Article
- Screening for Suicidal Thoughts and Behaviors in Older Adults in the Emergency Department.Journal of the American Geriatrics Society · 2016Article
- Disrupted Interhemispheric Synchrony in Default Mode Network Underlying the Impairment of Cognitive Flexibility in Late-Onset Depression.Frontiers in aging neuroscience · 2016Article
- Depression Treatment Among Rural Older Adults: Preferences and Factors Influencing Future Service Use.Clinical gerontologist · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Depression is a common, disabling, and costly condition encountered in older patients. Effective strategies for detection and treatment of late-life depression are summarized based on a case of a 69-year-old woman who struggled with prolonged depression. Clinicians should screen older patients for depression using a standard rating scale, initiate treatment such as antidepressant medications or evidence-based psychotherapy, and monitor depression symptoms. Patients who are not improving should be considered for psychiatric consultation and treatment changes including electroconvulsive therapy. Several changes in treatment approaches are usually needed before patients achieve complete remission. Maintenance treatment and relapse-prevention planning (summarization of early warning signs for depression, maintenance treatments such as medications, and other strategies to reduce the risk of relapse [eg, regular physical activity or pleasant activities]) can reduce the risk of relapse. Collaborative programs, in which primary care clinicians work closely with mental health specialists following a measurement-based treatment-to-target approach, are significantly more effective than typical primary care treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.