ArticleThe Journal of biological chemistry2012
Afadin is required for maintenance of dendritic structure and excitatory tone.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex.Neural development · 2020Article
- Chronic stress induces significant gene expression changes in the prefrontal cortex alongside alterations in adult hippocampal neurogenesis.Brain communications · 2020Article
- Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3.Neuropharmacology · 2018Article
- Article
- AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities inFrontiers in cellular neuroscience · 2017Article
- Control of Dendritic Spine Morphological and Functional Plasticity by Small GTPases.Neural plasticity · 2016Review
- Actin Out: Regulation of the Synaptic Cytoskeleton.The Journal of biological chemistry · 2015Review
- Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells.Journal of visualized experiments : JoVE · 2015Article
- Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.Cell reports · 2015Article
- Cadherin-based transsynaptic networks in establishing and modifying neural connectivity.Current topics in developmental biology · 2015Review
- Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.Neuron · 2014Article
- Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications.The Journal of biological chemistry · 2014Article
- Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.PloS one · 2014Article
- Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.Nature neuroscience · 2013Article
- Insights into rapid modulation of neuroplasticity by brain estrogens.Pharmacological reviews · 2013Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
The dendritic field of a neuron, which is determined by both dendritic architecture and synaptic strength, defines the synaptic input of a cell. Once established, a neuron's dendritic field is thought to remain relatively stable throughout a cell's lifetime. Perturbations in a dendritic structure or excitatory tone of a cell and thus its dendritic field are cellular alterations thought to be correlated with a number of psychiatric disorders. Although several proteins are known to regulate the development of dendritic arborization, much less is known about the mechanisms that maintain dendritic morphology and synaptic strength. In this study, we find that afadin, a component of N-cadherin·β-catenin·α-N-catenin adhesion complexes, is required for the maintenance of established dendritic arborization and synapse number. We further demonstrate that afadin directly interacts with AMPA receptors and that loss of this protein reduces the surface expression of GluA1- and GluA2-AMPA receptor subunits. Collectively, these data suggest that afadin is required for the maintenance of dendritic structure and excitatory tone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.