ArticleBiophysical journal2012
A kinetic model for type I and II IP3R accounting for mode changes.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Large deviations of piecewise-deterministic Markov processes with application to stochastic calcium waves.Journal of mathematical biology · 2026Article
- Modeling the spatiotemporal properties of crosstalk between RyR-mediated and IPFrontiers in cell and developmental biology · 2026Article
- Modelling ion channels with a view towards identifiability.Bulletin of mathematical biology · 2025Article
- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- Modeling traveling calcium waves in cellular structures.Journal of computational neuroscience · 2025Article
- A CaJournal of mathematical biology · 2025Article
- Modeling IPBiophysical journal · 2023Article
- A mathematical model of calcium signals around laser-induced epithelial wounds.Molecular biology of the cell · 2023Article
- An integrate-and-fire approach to CaBiophysical journal · 2023Article
- Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity.Exploration of targeted anti-tumor therapy · 2022Article
- Highly localized intracellular CaeLife · 2021Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- CaBiophysical journal · 2020Article
- Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity.PLoS computational biology · 2019Article
- A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes.PLoS computational biology · 2019Article
- Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease.Cell calcium · 2018Article
- Calcium as a signal integrator in developing epithelial tissues.Physical biology · 2018Review
- Analyzing optical imaging of CaCell calcium · 2017Article
- Mapping Interpuff Interval Distribution to the Properties of Inositol Trisphosphate Receptors.Biophysical journal · 2017Article
- The relative contributions of store-operated and voltage-gated CaThe Journal of physiology · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
Based upon an extensive single-channel data set, a Markov model for types I and II inositol trisphosphate receptors (IP(3)R) is developed. The model aims to represent accurately the kinetics of both receptor types of IP(3)R depending on the concentrations of inositol trisphosphate (IP(3)), adenosine trisphosphate (ATP), and intracellular calcium (Ca(2+)). In particular, the model takes into account that for some combinations of ligands the IP(3)R switches between extended periods of inactivity alternating with intervals of bursting activity (mode changes). In a first step, the inactive and active modes are modeled separately. It is found that, within modes, both receptor types are ligand-independent. In a second step, the submodels are connected by transition rates. Ligand-dependent regulation of the channel activity is achieved by modulating these transitions between active and inactive modes. As a result, a compact representation of the IP(3)R is obtained that accurately captures stochastic single-channel dynamics including mode changes in a model with six states and 10 rate constants, only two of which are ligand-dependent.
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