ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2012
Developing a 'traffic light' test with potential for rational early diagnosis of liver fibrosis and cirrhosis in the community.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
- Validation of the liver traffic light test as a predictive model for survival and development of liver-related events.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Article
- Transient elastography in patients at risk of liver fibrosis in primary care: a follow-up study over 54 months.BJGP open · 2021Article
- Sensory Stimulation of the Foot and Ankle Early Post-stroke: A Pilot and Feasibility Study.Frontiers in neurology · 2021Article
- Article
- GPs' experiences and perceptions of early detection of liver disease: a qualitative study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- Biomarker-Based Approaches for Assessing Alcohol Use Disorders.International journal of environmental research and public health · 2016Review
- Non-invasive Markers of Liver Fibrosis: Adjuncts or Alternatives to Liver Biopsy?Frontiers in pharmacology · 2016Review
- Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.World journal of gastroenterology · 2015Review
- Evaluation of work-based screening for early signs of alcohol-related liver disease in hazardous and harmful drinkers: the PrevAIL study.BMC public health · 2015Article
- Article
- Alcoholic liver disease - the extent of the problem and what you can do about it.Clinical medicine (London, England) · 2015Review
- Feasibility of detection and intervention for alcohol-related liver disease in the community: the Alcohol and Liver Disease Detection study (ALDDeS).The British journal of general practice : the journal of the Royal College of General Practitioners · 2013Article
- Therapeutic efficacy of fuzheng-huayu tablet based traditional chinese medicine syndrome differentiation on hepatitis-B-caused cirrhosis: a multicenter double-blind randomized controlled trail.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver disease develops silently and presents late, with often fatal complications.
aimTo develop a 'traffic light' test for liver disease suitable for community use that could enhance assessment of liver risk and allow rational referral of more severe disease to specialist care. DESIGN AND
settingTwo cohorts from Southampton University Hospital Trust Liver Unit: model development and a validation cohort to evaluate prognosis.
methodA total of 1038 consecutive liver patients (inpatient and outpatient) (development n = 397, validation n = 641) for whom the relevant blood tests had been performed, were followed for a mean of 46 months (range 13-89 months). Blood tests for: hyaluronic acid (HA), procollagen-3 N-terminal peptide (P3NP), and platelet count were combined in a diagnostic algorithm to stage liver disease.
resultsA simple clinical rule combined: HA, P3NP, and platelet count into a 'traffic light' algorithm, grading the results red--high risk, amber--intermediate risk, and green--low risk. In the validation cohort, no green subjects died or developed varices or ascites (n = 202); in the amber group, 9/267 (3.3%) died, 0/267 developed varices, and 2/267 (0.7%) developed ascites; in the red group, 24/172 died (14%), 24/172 (14%) developed varices, and 20/172 developed (11.6%) ascites. Survival was reduced in red (P<0.001) and amber (P<0.012) groups compared with green.
conclusionA simple blood test triages liver disease into three prognostic groups; used in the community, it could enhance the management of risk factors in primary care and rationalise secondary care referrals, including the many patients with fatty liver and relatively minor elevations in alanine transaminase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.