SynthesisBMC medical informatics and decision making2012
Deficiencies in the transfer and availability of clinical trials evidence: a review of existing systems and standards.
Synthesis in BMC medical informatics and decision making, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- A Permissioned Blockchain-Based Clinical Trial Service Platform to Improve Trial Data Transparency.BioMed research international · 2021Article
- Scientometric measures of prospectively registered clinical trials over time: A comparison of IRCT and ClinicalTrials.gov.Medical journal of the Islamic Republic of Iran · 2020Article
- Prototype of running clinical trials in an untrustworthy environment using blockchain.Nature communications · 2019Article
- Towards achieving semantic interoperability of clinical study data with FHIR.Journal of biomedical semantics · 2017Article
- Visualizing and Validating Metadata Traceability within the CDISC Standards.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2017Article
- Previously unidentified duplicate registrations of clinical trials: an exploratory analysis of registry data worldwide.Systematic reviews · 2016Article
- Semantic enrichment of longitudinal clinical study data using the CDISC standards and the semantic statistics vocabularies.Journal of biomedical semantics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDecisions concerning drug safety and efficacy are generally based on pivotal evidence provided by clinical trials. Unfortunately, finding the relevant clinical trials is difficult and their results are only available in text-based reports. Systematic reviews aim to provide a comprehensive overview of the evidence in a specific area, but may not provide the data required for decision making.
methodsWe review and analyze the existing information systems and standards for aggregate level clinical trials information from the perspective of systematic review and evidence-based decision making.
resultsThe technology currently used has major shortcomings, which cause deficiencies in the transfer, traceability and availability of clinical trials information. Specifically, data available to decision makers is insufficiently structured, and consequently the decisions cannot be properly traced back to the underlying evidence. Regulatory submission, trial publication, trial registration, and systematic review produce unstructured datasets that are insufficient for supporting evidence-based decision making.
conclusionsThe current situation is a hindrance to policy decision makers as it prevents fully transparent decision making and the development of more advanced decision support systems. Addressing the identified deficiencies would enable more efficient, informed, and transparent evidence-based medical decision making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.